Details About Generic Salt ::  Carbenic

Main Medicine Class::    

(car-BEN-ih-SILL-in IN-duh-nil SO-dee-uhm)
Geocillin,  Geopen Oral, Pyopen
Class: Antibiotic/penicillin

 

Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of acute and chronic infections of the upper and lower urinary tract, prostatitis and asymptomatic bacteriuria caused by susceptible microorganisms.

Drug Dose ::

 Route/Dosage

ADULTS: PO 382–764 mg qid.

Contraindication ::

 Contraindications Hypersensitivity to penicillins, cephalosporins or imipenem. Do not treat severe pneumonia, empyema, bacteremia, pericarditis, meningitis and purulent or septic arthritis with oral carbenicillin during acute stage.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy in infants and children < 12 yr not established. Cystic fibrosis: Associated with higher incidence of side effects with drug (eg, rash, fever). Renal impairment: Use drug cautiously; dosage adjustment may be required.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CNS: Dizziness; fatigue; insomnia; reversible hyperactivity. DERM: Urticaria; vesicular eruptions; erythema multiforme; skin rash. EENT: Itchy eyes; furry tongue; black “hairy” tongue; abnormal taste sensation; laryngeal edema; laryngospasm. GI: Gastritis; nausea; vomiting; abdominal pain or cramps; diarrhea or bloody diarrhea; flatulence; pseudomembranous colitis. GU: Interstitial nephritis (eg, oliguria, proteinuria, hematuria, hyaline casts, pyuria); nephropathy; increased BUN and creatinine. HEMA: Anemia; hemolytic anemia; thrombocytopenia; thrombocytopenic purpura; eosinophilia; leukopenia; granulocytopenia; neutropenia; bone marrow depression; agranulocytosis; reduced hemoglobin or hematocrit; prolonged bleeding and prothrombin time; increased or decreased lymphocyte count; increased monocytes, basophils, platelets. HEPA: Transient hepatitis and cholestatic jaundice. META: Elevated serum alkaline phosphatase and hypernatremia; reduced serum potassium, albumin, total proteins and uric acid. OTHER: Hypersensitivity reactions (urticaria, angioneurotic edema, laryngospasm, bronchospasm, hypotension, vascular collapse, death, maculopapular to exfoliative dermatitis, vesicular eruptions, erythema multiforme, serum sickness, laryngeal edema, skin rash, prostration); vaginitis; hyperthermia; fever.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::

 Interactions

Contraceptives, oral: May reduce efficacy of oral contraceptives. Use nonhormonal form of contraception during carbenicillin therapy. Tetracyclines: May impair bactericidal effects of carbenicillin.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies, especially to drugs in penicillin family or related drugs (eg, cephalosporins).
  • Obtain specimens for culture and sensitivity before beginning therapy.
  • Keep epinephrine, antihistamine, and resuscitation equipment close by in event of anaphylactic reaction.
  • Monitor renal function throughout therapy.
  • If rash, itching, hives, shortness of breath, wheezing or other signs of allergic reaction and anaphylaxis occur, withhold drug and notify physician.
  • If dizziness, black tongue, sore throat, nausea, diarrhea, vomiting, fever, swollen joints or any unusual bruising occurs, withhold drug and notify physician.

Drug Storage/Management ::

 Administration/Storage

  • Administer on empty stomach 1 hr before meals or 2 hr after meals. Give with full glass of water.

Drug Notes ::

 Patient/Family Education

  • If allergy to carbenicillin is demonstrated, inform patient that this allergy extends to all penicillins, cephalosporins and imipenem.
  • Advise patient to take medication with full glass of water, not with food, fruit juice or carbonated beverages because doing so may inactivate drug.
  • Caution patient to stop taking drug and notify physician if difficulty breathing, rash or other allergic response occurs.
  • Advise patient to take medication at even intervals if possible.
  • Instruct patient to report these symptoms to physician: decreased urinary output, nausea, vomiting, unpleasant aftertaste and smell, dry mouth, “furry” tongue, unexplained bruising or nosebleeds, foul-smelling diarrhea/stool or vaginal discharge.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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