Details About Generic Salt ::  Cefopera

Main Medicine Class::    

(SEFF-oh-PURR-uh-zone SO-deeuhm)
Class: Antibiotic/cephalosporin


Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of infections of respiratory tract, urinary tract, skin and skin structures, treatment of pelvic inflammatory disease, endometritis and other female genital tract infections; treatment of septicemia and peritonitis due to susceptible microorganisms.

Drug Dose ::


ADULTS: IV/IM 2–4 g/day in equally divided doses q 12 hr (severe infections: 6–12 g/day in equally divided doses [1.5–4 g/dose] q 6, 8 or 12 hr).

Contraindication ::

 Contraindications Hypersensitivity to cephalosporins.

Drug Precautions ::


Pregnancy: Category B. Lactation: Small quantities may be excreted in breast milk. Children: Safety and efficacy in children not established. Coagulation abnormalities: Cefoperazone may interfere with hemostasis. Bleeding abnormalities are greater risk in presence of hepatic and renal dysfunction, thrombocytopenia, concomitant use of anticoagulants or other drugs that affect hemostasis (eg, aspirin) and in elderly, malnourished or debilitated patients. Hepatic impairment: Since cefoperazone is extensively excreted in bile, serum concentrations may be elevated; monitor levels at doses > 4 g. Hypersensitivity: Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients due to possible cross-reactivity. Pseudomembranous colitis: Should be considered in patients in whom diarrhea develops. Superinfection: May result in bacterial or fungal overgrowth of nonsusceptible microorganisms.


Drug Side Effects ::

 Adverse Reactions

GI: Nausea, vomiting, diarrhea; pseudomembranous colitis. GU: Renal dysfunction; elevation in serum creatinine. HEMA: Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage. HEPA: Hepatitis; abnormal liver function test results. OTHER: Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness-like reactions (eg, skin rashes, polyarthritis; arthralgia, fever); phlebitis, thrombophlebitis and pain at injection site.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::


Alcohol: May cause acute alcohol intolerance (disulfiram-like reaction); reaction may occur up to 3 days after last dose of cefoperazone. Aminoglycosides: May increase risk of nephrotoxicity. Anticoagulants, oral: May increase anticoagulant effect; bleeding complications may occur. INCOMPATIBILITIES: Aminoglycosides: Do not add aminoglycosides to cefoperazone solutions because inactivation of both drugs may result; administer at separate sites if concurrent therapy is indicated.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies. Note allergy to cephalosporins and penicillins.
  • Obtain specimens for culture and sensitivity before beginning therapy and periodically during treatment.
  • Monitor renal function carefully during treatment.
  • Monitor for signs of infection, especially fever, and for positive response to antibiotic therapy.
  • Assess for signs and symptoms of anaphylaxis (shortness of breath, wheezing, laryngeal spasm). Have resuscitation equipment available.
  • Assess for signs of superinfection, such as vaginitis or stomatitis.
  • Assess for diarrhea with blood or pus, which may be symptom of pseudomembranous colitis. Symptoms may occur after antibiotic treatment.
  • Monitor IV site for infiltration, infection, and thrombophlebitis.
  • Monitor for coagulation abnormalities. Elevated prothrombin time or abnormal platelet count may occur. If bleeding occurs and PT is prolonged, vitamin K may be indicated.

Drug Storage/Management ::


  • If drug is administered intramuscularly with concentration > 250 mg/ml, give with 0.5% lidocaine or any other suitable diluent.
  • For IV infusion, dilute reconstituted drug in 50–100 ml 0.9% sodium chloride or D5W and infuse over 30 min.
  • For IM administration, inject deeply within body of large muscle (eg, gluteus muscle).
  • May freeze medication. Thaw at room temperature and discard unused portions. Do not refreeze.
  • Before reconstitution, protect from light and store at cool temperature.
  • Solutions are stable for 24 hr at room temperature and 5 days if refrigerated. Do not administer if solution is cloudy or precipitate is present.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to check body temperature daily. If fever persists for more than a few days or if high fever (> 102°F) or shaking chills are noted, physician should be notified immediately.
  • Advise patient to maintain normal fluid intake while using this medication.
  • Advise diabetic patient to use enzyme-based tests (eg, Clinistix, Testape) for monitoring urine glucose because drug may give false results with other tests.
  • Instruct patient to report these symptoms to physician: nausea, vomiting, diarrhea, skin rash, hives, sore throat, bruising, bleeding, muscle or joint pain.
  • Warn patient that diarrhea that contains blood or pus may be a sign of serious disorders. Tell patient to seek medical care and not to treat at home.
  • Instruct patient to seek emergency care if wheezing or difficulty in breathing occurs.
  • Advise patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.
  • Instruct patient not to drink alcoholic beverages or to take alcohol-containing medications while taking this medication and for several days after discontinuing it.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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