Details About Generic Salt ::  Dornase

Main Medicine Class:: Respiratory inhalant,enzyme   

(DOR-nace AL-fuh)
Pulmozyme
Class: Respiratory inhalant/enzyme

 

Drugs Class ::

 Action Cleaves DNA released by neutrophils that are mobilized to respiratory tract in response to infection, reducing viscoelasticity of purulent lung secretions, increasing airflow and decreasing risk of infection.

Indications for Drugs ::

 Indications Treatment of cystic fibrosis.

Drug Dose ::

 Route/Dosage

ADULTS & CHILDREN > 5 YR: Inhalation 2.5 mg once daily by oral inhalation via nebulizer; patients > 21 yr and those with baseline forced vital capacity > 85% benefit from 2.5 mg bid.

Contraindication ::

 Contraindications Hypersensitivity to Chinese hamster ovary cell products.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Undetermined. Children: Safety and efficacy in children < 5 yr not established.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Chest pain. DERM: Rash. EENT: Conjunctivitis; sore throat; voice alterations; hoarseness. RESP Hoarseness; pharyngitis; laryngitis.

Drug Mode of Action ::  

 Action Cleaves DNA released by neutrophils that are mobilized to respiratory tract in response to infection, reducing viscoelasticity of purulent lung secretions, increasing airflow and decreasing risk of infection.

Drug Interactions ::

 Interactions

None well documented.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Assess patient’s ability to clear secretions. Provide assistance with coughing, positioning (semi-Fowler’s or sitting upright) and suctioning.
  • Provide hydration to liquefy secretions and replace fluids.
  • Perform auscultation to determine quality of breath sounds. Note characteristics of cough and sputum.
  • Perform chest physiotherapy (percussion and postural drainage) as ordered.

Drug Storage/Management ::

 Administration/Storage

  • Use in conjunction with standard therapies for cystic fibrosis.
  • Discard solution if cloudy or discolored.
  • Discard unused portions of ampules.
  • Do not dilute or mix drug with other drugs in nebulizer.
  • Keep refrigerated and protected from strong light. Storing at room temperature for < 24 hr does not adversely affect product.

Drug Notes ::

 Patient/Family Education

  • Teach patient to follow manufacturer’s instructions on use and maintenance of nebulizer and compression system.
  • Instruct patient in proper administration and storage of drug.
  • Tell patient that drug may cause sore throat, voice alterations or hoarseness and to inform physician if these or any other symptoms become bothersome.
  • Inform patient that benefits of treatment may not become apparent for months.
  • Emphasize importance of avoiding contraction of respiratory infections.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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