Details About Generic Salt ::  Dronabin

Main Medicine Class:: Antiemetic,Antivertigo; Appetite stimulant   

(droe-NAB-ih-nahl)
Marinol
Class: Antiemetic/Antivertigo; Appetite stimulant

 

Drugs Class ::

 Action Principal psychoactive substance derived from cannabis (marijuana); mechanism by which it prevents nausea and vomiting is unknown.

Indications for Drugs ::

 Indications Control of chemotherapy-induced nausea and vomiting unresponsive to other antiemetics; appetite stimulation in AIDS cachexia.

Drug Dose ::

 Route/Dosage

Antiemetic

ADULTS & CHILDREN: PO 5 mg/m2 1 to 3 hr before chemotherapy and q 2 to 4 hr after chemotherapy. Can give 4 to 6 doses/day and increase by 2.5 mg/m2/dose; do not exceed 15 mg/m2/dose.

Appetite Stimulation

ADULTS: PO 2.5 mg bid. Can give single daily dose of 2.5 mg to patients in whom adverse effects develop. Can increase by 2.5 mg/day; do not exceed 20 mg/day.

Contraindication ::

 Contraindications Hypersensitivity to marijuana or sesame oil.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Not recommended in children with AIDS cachexia. Elderly patients: More sensitive to psychoactive effects. Drug dependence: Drug has abuse potential.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Tachycardia; hypotension. CNS: Euphoria; dizziness; paranoid reaction; somnolence; seizures in patients with existing seizure disorders. OTHER: Tolerance, psychological and physical dependence with chronic use.

Drug Mode of Action ::  

 Action Principal psychoactive substance derived from cannabis (marijuana); mechanism by which it prevents nausea and vomiting is unknown.

Drug Interactions ::

 Interactions

Amphetamines, cocaine, sympathomimetics: Hypertension; tachycardia. CNS depressants: Increased CNS adverse effects.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note history of drug or alcohol abuse.
  • Assess for nausea, vomiting, appetite, bowel sounds and abdominal pain before and after drug is administered.
  • Monitor BP and pulse rate during therapy, especially in patients with hypotension or cardiac disease.
  • Monitor I&O, hydration, nutritional status and weight regularly.
  • Monitor side effects, which vary with each patient and are usually dose related. Side effects may be exacerbated in elderly, manic, depressive or schizophrenic patients.
  • Administer IV fluids as ordered for severe nausea and vomiting.
  • Assess for signs of withdrawal syndrome, including: irritability, restlessness, insomnia, hot flashes, sweating, rhinorrhea, loose stools, hiccoughs, anorexia.
  • Limit quantity of drug available to patient to amount necessary for single cycle of chemotherapy.
  • Assist patient with ambulation. Implement safety measures (eg, side-rails) to prevent falls, especially in elderly patients.

OVERDOSAGE: SIGNS & SYMPTOMS
  Mild intoxication: Drowsiness, euphoria, heightened sensory awareness, altered time perception, reddened conjunctiva, dry mouth, tachycardia. Moderate intoxication: Memory impairment, depersonalization, mood alteration, urinary retention, reduced bowel motility. Severe intoxication: Decreased motor coordination, lethargy, slurred speech, postural hypotension. Apprehensive patients may experience panic reactions. Patients with seizure disorder may experience seizures

Drug Storage/Management ::

 Administration/Storage

  • When given as appetite stimulant, administer bid before lunch and supper.
  • Refrigerate capsules; do not freeze.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to take drug exactly as ordered by physician.
  • Discuss psychoactive symptoms with patient and family. Symptoms may be minimized by providing quiet, supportive environment.
  • Explain that signs of overdose (mood changes, confusion, hallucinations, depression, nervousness, fast or pounding heartbeat) may occur with increased doses.
  • Instruct patient to make position changes slowly to prevent orthostatic hypotension.
  • Advise patient and family that adult supervision is necessary as patient may experience drowsiness, dizziness, difficulty concentrating, and perceptual and coordination impairment.
  • Instruct patient to avoid intake of alcoholic beverages, barbiturates and other CNS depressants.
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

We would like to keep you updated with special notifications.