Details About Generic Salt ::  Guanaben

Main Medicine Class:: Antihypertensive,Antiadrenergic, centrally acting   

(GWAHN-uh-benz ASS-uh-TATE)
Class: Antihypertensive/Antiadrenergic, centrally acting


Drugs Class ::

 Action Appears to stimulate central alpha2-adrenergic receptors, inhibiting sympathetic outflow from brain to peripheral circulation.

Indications for Drugs ::

 Indications Treatment of hypertension alone or with a thiazide diuretic.

Drug Dose ::


ADULTS: PO 4 mg bid initially; may increase by 4 to 8 mg daily every 1 to 2 wk; maximum dose 32 mg bid.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::


Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy in children < 12 yr not established. Special risk patients: Use with caution in patients with severe coronary insufficiency, recent MI, or cerebrovascular disease. Sedation: Occurs in large percentage of patients. Withdrawal: Do not discontinue therapy without consulting health care provider; drug must be withdrawn gradually to avoid rapid rise in BP.


Drug Side Effects ::

 Adverse Reactions

CV: Chest pain; edema; arrhythmias; palpitations; atrioventricular dysfunction. CNS: Drowsiness; sedation; dizziness; anxiety; ataxia; depression; sleep disturbances. DERM: Rash; pruritus. EENT: Blurred vision; nasal congestion. GI: Dry mouth; constipation; diarrhea; nausea; vomiting; abdominal discomfort. GU: Urinary frequency; disturbances of sexual function. HEPA: Increased liver enzymes. RESP: Dyspnea. OTHER: Gynecomastia; muscle or joint pain; weakness; taste disorders.

Drug Mode of Action ::  

 Action Appears to stimulate central alpha2-adrenergic receptors, inhibiting sympathetic outflow from brain to peripheral circulation.

Drug Interactions ::


CNS depressants: Increased sedation.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies. Note any cardiovascular or cerebrovascular disease.
  • Take patient’s BP (lying, sitting, standing) and pulse before administering drug. Monitor periodically throughout therapy.
  • Assess for dry mouth and follow treatment measures as necessary.
  • Report these signs to health care provider immediately: Hypotension, chest pain, arrhythmias, edema, dyspnea.

  Marked hypotension, somnolence, lethargy, irritability, miosis, bradycardia

Drug Storage/Management ::


  • Administer with food or milk.
  • Store in tightly closed container in cool environment.

Drug Notes ::

 Patient/Family Education

  • Instruct patient and family member in proper technique for taking BP. Advise patient to check and record BP weekly.
  • Advise patient to lie down if dizziness or blurred vision occurs.
  • Explain that impotence may occur but is reversible. Tell patient to report to health care provider.
  • Instruct patient not to discontinue drug abruptly.
  • Counsel patient about benefits of weight reduction, exercise, reduction of alcohol and sodium, cessation of smoking.
  • Instruct patient to report these symptoms to health care provider: Headache, dizziness, weakness, blurred vision.
  • Advise patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
  • Caution patient to avoid sudden position changes to prevent orthostatic hypotension.
  • Instruct patient to avoid intake of alcoholic beverages or other CNS depressants.
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.
  • Instruct patient not to take otc medications without consulting health care provider.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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