Details About Generic Salt ::  Guanfaci

Main Medicine Class:: Antihypertensive,Antiadrenergic, centrally acting   

(GWAHN-fay-seen HIGH-droe-KLOR-ide)
Tenex
Class: Antihypertensive/Antiadrenergic, centrally acting

 

Drugs Class ::

 Action Appears to stimulate central alpha2-adrenergic receptors, with decreased sympathetic outflow, causing decrease in peripheral vascular resistance and reduction in heart rate.

Indications for Drugs ::

 Indications Treatment of hypertension. unlabeled use(s): Amelioration of heroin withdrawal symptoms.

Drug Dose ::

 Route/Dosage

ADULTS: PO 1 mg daily at bedtime; may increase gradually up to 3 mg daily.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy in children < 12 yr not established. Special risk patients: Use with caution in patients with severe coronary insufficiency, recent MI, cerebrovascular disease or chronic renal or hepatic impairment. Sedation: Occurs in a large percentage of patients. Withdrawal: Do not discontinue therapy without consulting health care provider; drug must be withdrawn gradually to avoid rapid rise in BP (rebound hypertension).

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Chest pain; bradycardia; palpitations. CNS: Somnolence; drowsiness; dizziness; headache; sleep disturbances; insomnia; confusion; depression. DERM: Dermatitis; pruritus; sweating. EENT: Conjunctivitis; visual disturbance; tinnitus; rhinitis; taste perversion. GI: Dry mouth; constipation; diarrhea; nausea; abdominal discomfort; dyspnea. GU: Urinary incontinence; testicular disorder; decreased libido; impotence. OTHER: Paresthesia; paresis; leg cramps; hypokinesia.

Drug Mode of Action ::  

 Action Appears to stimulate central alpha2-adrenergic receptors, with decreased sympathetic outflow, causing decrease in peripheral vascular resistance and reduction in heart rate.

Drug Interactions ::

 Interactions

Alcohol, CNS depressants: Increased CNS depression. Barbiturates, phenytoin: Decreased guanfacine levels with loss of antihypertensive effect.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note cardiovascular, cerebrovascular, renal, or hepatic disease.
  • Take patient’s BP (lying, sitting, standing) and pulse before administering drug. Monitor periodically throughout therapy.
  • Notify health care provider if these signs occur: Hypotension, chest pain, palpitations, anemia, leukopenia, thrombocytopenia, edema, dyspnea, diarrhea.
OVERDOSAGE: SIGNS & SYMPTOMS
  Severe drowsiness, hypotension, bradycardia

Drug Storage/Management ::

 Administration/Storage

  • Administer medication at bedtime.
  • Give with food or milk if patient experiences stomach upset.
  • Store in tightly closed container and protect from light.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to take medication at bedtime.
  • Teach patient proper technique for taking BP. Advise patient to check BP weekly.
  • Instruct patient not to discontinue drug abruptly.
  • Advise patient on benefits of weight loss, exercise, reduction of alcohol and sodium intake and cessation of smoking.
  • Instruct patient to lie down if dizziness or blurred vision occurs.
  • Explain that impotence may occur but is reversible. Tell patient to report to health care provider.
  • Instruct patient to report these symptoms to health care provider: Dizziness, constipation, headache, insomnia, nausea, sweating, or weakness.
  • Advise patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
  • Caution patient to avoid sudden position changes to avoid orthostatic hypotension.
  • Instruct patient to avoid intake of alcoholic beverages or other CNS depressants.
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.
  • Instruct patient not to take otc medications without consulting health care provider.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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