Details About Generic Salt ::  Mesalami

Main Medicine Class:: Intestinal anti-inflammatory,aminosalicylic acid derivative   

(me-SAL-uh-MEEN)
Asacol, Pentasa, Rowasa,  Mesacal, Novo-5 ASA, Quintasa, Salofalk
Class: Intestinal anti-inflammatory/aminosalicylic acid derivative

 

Drugs Class ::

 Action Reduces inflammation of colon topically by preventing production of substances involved in inflammatory process such as arachidonic acid.

Indications for Drugs ::

 Indications Treatment of active, mild to moderate distal ulcerative colitis, proctosigmoiditis or proctitis. Unlabeled use(s): Treatment of Crohn’s disease.

Drug Dose ::

 Route/Dosage

ADULTS: CONTROLLED RELEASE TABLETS OR CAPSULES: PO 800 mg tid for total of 2.4 g/day for 6 wk. SUPPOSITORIES: PR 500 mg suppository bid for up to 6 wk. Retain suppository in rectum for 1–3 hr or more to achieve maximum benefit. SUSPENSION ENEMA: PR 4 g in 60 ml as rectal instillation q day for up to 6 wk, preferably at bedtime, retained for 8 hr.

Contraindication ::

 Contraindications Hypersensitivity to salicylates.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Intolerance and colitis exacerbation: Some patients develop acute intolerance syndrome or exacerbation of colitis characterized by cramping, acute abdominal pain and bloody diarrhea, and occasionally fever, headache, malaise, pruritus, conjunctivitis and rash. Symptoms generally abate when mesalamine is discontinued. Pericarditis: Rarely, pericarditis has been reported. Observe for chest pain or dyspnea. Pyloric stenosis: Gastric retention of oral mesalamine may occur in patients with pyloric stenosis. Renal impairment: Patients with history of renal disease or dysfunction may have worsening of renal function. Sulfite sensitivity: Some products may contain sulfites, which may cause allergic reactions in susceptible individuals.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Chest pain. CNS: Headache; asthenia; chills; dizziness; fever; sweating; malaise. DERM: Acne; itching; rash. EENT: Rhinitis; sore throat; pharyngitis. GI: Abdominal pain; cramps; discomfort; colitis exacerbation; constipation; iarrhea; dyspepsia; vomiting; flatulence; nausea; eructation; rectal pain; oreness; burning. RESP: Cough. OTHER: Arthralgia; back pain; hypertonia; myalgia; dysmenorrhea; edema; flu syndrome; pain.

Drug Mode of Action ::  

 Action Reduces inflammation of colon topically by preventing production of substances involved in inflammatory process such as arachidonic acid.

Drug Interactions ::

 Interactions None well documented.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Monitor results of renal function tests throughout therapy.
  • Assess for increased abdominal pain, nausea, diarrhea and vomiting and notify physician of any problems.
  • Document character and frequency of stools.

Drug Storage/Management ::

 Administration/Storage

  • Instruct patient to swallow tablets or capsules whole.
  • Do not alter form of medication prior to administration.
  • Shake suspension well and position patient in knee-chest position or on left side with lower leg extended and upper right leg flexed for administration.
  • Be certain that suppositories are retained for 1–3 hr and enemas retained for about 8 hr (preferably at bedtime) to achieve maximum effectiveness.
  • Full course of therapy may last up to 6 wk and patient response may occur within 3–12 days.
  • Store at room temperature.

Drug Notes ::

 Patient/Family Education

  • Tell patient to swallow capsules or tablets whole. Explain that outer coating must be intact to pass through stomach and travel to sigmoid colon.
  • Tell patient to notify physician if any remnant of capsule or tablet is seen in stool.
  • Tell patient to retain suppository 1–3 hr or to retain enema for 8 hr.
  • Teach patient proper positioning and technique for self-administering enema. Include knee-chest and left side positions to promote medication advancement to sigmoid colon.
  • Tell patient to report these symptoms to physician: increase in abdominal pain, diarrhea or vomiting.
  • Instruct patient to notify physician of hives, itching, wheezing, rash or fever.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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