Details About Generic Salt ::  Selegili

Main Medicine Class:: Antiparkinson   

(seh-LEH-jih-leen HIGH-droe-KLOR-ide)
Carbex, Eldepryl, Selegiline HCl
Class: Antiparkinson


Drugs Class ::

 Action Selective type B monoamine oxidase (MAO) inhibitor thought to increase dopaminergic activity. MAO enzyme breaks down catecholamines and serotonin. Selegiline may also interfere with dopamine reuptake at synapse.

Indications for Drugs ::

 Indications Adjunct to levodopa/carbidopa in idiopathic Parkinson’s disease, postencephalic parkinsonism/symptomatic parkinsonism.

Drug Dose ::


ADULTS: PO 10 mg/day as divided dose of 5 mg each taken at breakfast and lunch. Do not exceed 10 mg/day. After 2 to 3 days of treatment, try reducing levodopa/carbidopa dose by 10 to 30%. Further reductions may be possible during continued selegiline therapy.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::


Pregnancy: Category C. Lactation: Undetermined. Children: Effects have not been evaluated. Maximum: Do not exceed recommended daily dose of 10 mg/day because of risks associated with nonselective inhibition of MAO (potentially serious food or drug interactions may occur at higher doses). Hypertensive crisis risk: Selegiline can be given with active amine-containing medications and tyramine foods as long as recommended dose is not exceeded. However, report any possible symptoms suggestive of hypertensive crisis.


Drug Side Effects ::

 Adverse Reactions

CV: Palpitations; orthostatic hypotension; arrhythmia; hypertension; new or increased angina; syncope. CNS: Dizziness; lightheadedness; fainting; confusion; hallucinations; vivid dreams; headache; anxiety; tension; insomnia; lethargy; depression; loss of balance; delusions; dyskinesias; increased akinetic involuntary movements; bradykinesia; chorea. DERM: Sweating; rash; photosensitivity. EENT: Diplopia; blurred vision. GI: Nausea; abdominal pain; dry mouth; diarrhea. GU: Sexual dysfunction; urinary retention, frequency, hesitancy. OTHER: Generalized ache; leg pain; low back pain; weight loss.

Drug Mode of Action ::  

 Action Selective type B monoamine oxidase (MAO) inhibitor thought to increase dopaminergic activity. MAO enzyme breaks down catecholamines and serotonin. Selegiline may also interfere with dopamine reuptake at synapse.

Drug Interactions ::


Fluoxetine: May produce a “serotonin” syndrome (CNS irritability, increased muscle tone, altered consciousness). Meperidine: Could result in agitation, seizures, diaphoresis and fever, which may progress to coma, apnea and death. Reactions may occur several wks following withdrawal of selegiline.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Monitor vital signs, especially BP and respirations.
  • Assess patient for decrease in akathisia and mood.
  • Assess patient’s mental status: affect, mood, behavioral changes, depression.
  • Dosage of levodopa/carbidopa may be reduced after 2 to 3 days of treatment.
  • Assess for side effects, particularly nausea, dizziness, lightheadedness, abdominal pain, confusion, hallucination.
  • Assist patient with ambulation at beginning of therapy.
  • Assess diet for tyramine-containing foods.
  • Implement safety measures to prevent falls, especially during initial treatment.
  Hypotension, psychomotor agitation

Drug Storage/Management ::


  • Administer 5 mg with breakfast and with lunch.
  • Do not exceed 10 mg daily.

Drug Notes ::

 Patient/Family Education

  • Encourage patient to change position slowly to prevent orthostatic hypotension.
  • Instruct patient to avoid driving or other potentially hazardous activities until effect of medication is determined.
  • Explain that dosage of levodopa/carbidopa may be reduced after initiation of adjunctive therapy.
  • Identify tyramine-containing foods; explain rationale for exclusion from diet.
  • Instruct patient to report these side effects: twitching, eye spasms.
  • Caution patient to use drug exactly as prescribed. Explain that if drug is discontinued, parkinsonian crisis may occur.
  • Advise patient not to exceed 10 mg/day dose.
  • Inform patient and family of symptoms of hypertensive crisis and when to call physician. Instruct them to report severe headache or other unusual symptoms.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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