Details About Generic Salt ::  Oxaprozi

Main Medicine Class:: Analgesic,NSAID   

(ox-uh-PRO-zin)
Daypro
Class: Analgesic/NSAID

 

Drugs Class ::

 Action Decreases inflammation, pain and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Indications for Drugs ::

 Indications Relief of symptoms of rheumatoid arthritis and osteoarthritis.

Drug Dose ::

 Route/Dosage

ADULTS: PO 1200 mg once a day (maximum 1800 mg/day or 26 mg/kg, whichever is lower).

Contraindication ::

 Contraindications Hypersensitivity to aspirin, iodides, or any other NSAID.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. GI effects: Serious GI toxicity (eg, bleeding, ulceration, perforation) can occur at any time, with or without warning symptoms. Elderly: Increased risk of adverse reactions. Hepatic function impairment: Exercise caution when administering to patients with impaired hepatic function or history of liver disease. Platelet aggregation: Can inhibit platelet aggregation; use with caution in patients with intrinsic coagulation defects or those on anticoagulant therapy. Renal impairment: May need to reduce dose.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CV: Edema; blood pressure changes; worsening or precipitation of CHF. CNS: Depression; sedation; somnolence; confusion; disturbed sleep. DERM: Rash; pruritus; erythema; photosensitivity; ecchymosis. EENT: Visual disturbances; tinnitus. GI: Gastric distress; peptic ulcers; occult blood loss; diarrhea; constipation; vomiting; nausea; dyspepsia; flatulence; anorexia; abdominal distress/cramps/pain; stomatitis. GU: Difficult or painful urination; urinary frequency; decreased menstrual flow. HEMA: Anemia; neutropenia; thrombocytopenia; leukopenia. HEPA: Hepatitis.

Drug Mode of Action ::  

 Action Decreases inflammation, pain and fever, probably through inhibition of cyclooxygenase activity and prostaglandin synthesis.

Drug Interactions ::

 Interactions

Beta-blockers: Antihypertensive effects may be decreased. Lithium: May increase lithium levels. Loop diuretics: Diuretic effects may be decreased. Methotrexate: May increase methotrexate levels. Warfarin: May increase risk of gastric erosion and bleeding.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history.
  • Closely monitor patients at risk for peptic ulcer disease such as those with a history of serious GI problems, alcoholism, smoking or other ulcer-associated factors.
  • Determine if patient is taking aspirin, oral anticoagulants, H2-receptor antagonists, beta-blockers, iodides, or other NSAIDs as drug interactions can occur and discontinuation or adjustment in therapy would be indicated.
  • Assess for adverse reactions. Notify physician if the following adverse reactions occur: Abdominal pain, anorexia, dyspepsia, flatulence, nausea, vomiting, depression, sedation, somnolence, confusion, sleep disturbances, rash, tinnitus and dysuria, frequency of urination.
  • Ensure dosage is individualized to the lowest effective dose to minimize adverse effects.
  • Anticipate a greater risk of reactions from patients on higher dosages or elderly patients.
  • Monitor renal function tests (eg, creatinine, BUN).
  • Monitor CBC, especially hemoglobin, hematocrit and platelets.
  • If patient is taking beta-blockers, monitor blood pressure when starting therapy for increases in sitting and standing blood pressure.
OVERDOSAGE: SIGNS & SYMPTOMS
  Drowsiness, nausea, heartburn, vomiting, indigestion, seizures

Drug Storage/Management ::

 Administration/Storage

  • Food may reduce the rate of absorption but not the extent. Antacids have no effect on rate or extent of absorption.
  • Not recommended for patients with renal or hepatic disease, low body weight, advanced age, a known ulcer susceptibility or known sensitivity to other NSAIDs.
  • Store < 86°F in a tight, light-resistant container.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to take medication as prescribed and not to make up missed doses.
  • Inform patient that analgesic effects are usually achieved after a single dose, but that it requires several days of dosing to reach the maximum effect.
  • Inform patient concerning the expected therapeutic effects of the medication, which include analgesic, antipyretic and anti-inflammatory benefits.
  • Instruct patient to inform the health care provider of symptom relief so that the dosage is individualized to the lowest effective dose to minimize adverse effects.
  • Instruct patient to take the dose exactly as prescribed about the same time each day with a full glass of water.
  • Caution patient to avoid taking other NSAIDs, aspirin, alcohol, or other otc medications unless advised to do so by the health care provider.
  • Instruct patient concerning drug/drug interactions as applicable to their situation.
  • Advise patient to discontinue drug and notify health care provider if any of the following occurs: Persistent GI upset or headache, skin rash, itching, visual disturbances, black stools, weight gain or edema, changes in urine pattern, joint pain, fever, or blood in urine.
  • Caution patient regarding the serious GI, renal, hepatic, hematologic and dermatologic adverse effects that can occur at any time, with or without warning symptoms.
  • Advise patient on long-term therapy that lab tests may be required and to keep appointments.
  • Caution patient to inform their dentist or surgeon prior to any procedure that they are taking oxaprozin.
  • Advise elderly or debilitated patients regarding their increased risk of adverse reactions.
  • Caution patient regarding possibility of photosensitivity and to use protective measures until tolerance is determined.
  • Advise patient that medication may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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