Details About Generic Salt ::  Vasopres

Main Medicine Class:: Posterior pituitary hormone   

Pitressin Synthetic
Class: Posterior pituitary hormone


Drugs Class ::

 Action Promotes resorption of water through kidney. At high doses, stimulates contraction of smooth muscle causing vasoconstriction, increased peristaltic activity, and gall-bladder contractions.

Indications for Drugs ::

 Indications Treatment of neurogenic diabetes insipidus; prevention and treatment of postoperative abdominal distention; facilitation of abdominal roentgenography.

Treatment of bleeding esophageal varices.

Drug Dose ::


Diabetes Insipidus

ADULTS & CHILDREN: IM/SC 2.5 to 10 units 2 to 4 times daily as needed.

Abdominal Distention

ADULTS: IM 5 units initially; subsequent injections q 3 to 4 hr prn. May increase the dose to 10 units if necessary.

Abdominal Roentgenography

ADULTS: IM/SC 2 injections of 10 units each administered 2 hr and 30 min before films are exposed.

Bleeding Esophageal Varices

ADULTS: IV Infuse initially at 0.2 to 0.4 U/min and increase to 0.9 U/min if necessary.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::


Pregnancy: Category C. Lactation: Undetermined. Special risk patients: Use drug with caution in patients with epilepsy, migraine, asthma, heart failure, or any condition where a rapid rise in extracellular water may result in further compromise. Chronic nephritis with nitrogen retention: Contraindicates use until reasonable nitrogen blood levels have been attained. Extravasation: Severe vasoconstriction and local tissue necrosis may result if drug extravasates during IV infusion. Hypersensitivity: Local or systemic reactions, including anaphylaxis, may occur. Vascular disease: Use extreme caution in patients with vascular disease. Water intoxication: May occur. Early signs include confusion, drowsiness, listlessness, and headache.


Drug Side Effects ::

 Adverse Reactions

CV: ANGINA. GI: Abdominal cramps; nausea; vomiting; gas. OTHER: Gangrene; ischemic colitis; tissue necrosis (with extravasation); allergic reaction (cardiac arrest, tremor, vertigo, sweating).

Drug Mode of Action ::  

 Action Promotes resorption of water through kidney. At high doses, stimulates contraction of smooth muscle causing vasoconstriction, increased peristaltic activity, and gall-bladder contractions.

Drug Interactions ::


Carbamazepine, chlorpropamide: May potentiate antidiuretic effect of vasopressin.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Monitor for allergic reactions, including tremor, sweating, vertigo, circumoral pallor, “pounding in head,” abdominal cramps, flatus, nausea, vomiting, urticaria, bronchial constriction.
  • Monitor I & O, and weigh daily.
  • Monitor urine specific gravity and osmolarity.
  • Monitor vital signs.
  • Monitor ECG and fluid and electrolyte status at frequent intervals during prolonged therapy.
  • Monitor patient for evidence of water intoxication (confusion, drowsiness, listlessness, headache). Report to health care provider immediately if noted.
  • Monitor for therapeutic response: Decreased urine output;decreased thirst.
  • Assess reduction of thirst.
  • In abdominal distention, assess bowel sounds and presence or absence of flatus.
  Confusion, lethargy, drowsiness, listlessness, headache

Drug Storage/Management ::


  • Store at room temperature. Do not freeze.
  • Give 1 to 2 glasses of water with dose to prevent skin blanching, abdominal cramps, and nausea.
  • If administering via IV infusion, 0.9% Normal Saline or D5W to a concentration of 0.1 to 1 U/ml. Insure patency of venous access and use infusion control device.

Drug Notes ::

 Patient/Family Education

  • Tell patient to take with 1 to 2 glasses of water to prevent skin blanching, nausea, abdominal cramping.
  • Caution patient to withhold medication and to notify health care provider of chest pain.
  • Tell patient to report drowsiness, listlessness, and headache to health care provider and to restrict water intake.
  • Explain that urine output should decrease after use.
  • Tell patient to monitor weight daily.
  • Instruct patient to avoid alcohol intake during therapy.
  • Remind patients with diabetes insipidus to carry appropriate medical identification.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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