The Brand Name HANSEPRAN Has Generic Salt :: Clofazimine 

HANSEPRAN  Is From Company Nicholas Priced :: Rs. 30.7

HANSEPRAN have Clofazimine is comes under Sub class Anti Leprotics of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Anti Leprotics 

 Salt Name :  OR Generic Name Form Price : MRP /Probable Packing
Clofazimine  CAP  Rs. 30.7  10
Brand Name Company / Manufacturers Strength Unit Price / 10
 HANSEPRAN  Nicholas  100MG  10 Rs. 30.7

Company  Brand Name  Salt Combination Main Medical Class Sub Medical Class
 From Nicholas :: HANSEPRAN  Clofazimine  Anti Infectives Anti Leprotics

Indications for Drugs ::

Leprosy

Drug Dose ::

Adult: PO Multibacillary leprosy 300 mg (w/ rifampicin 600 mg) once mthly combined w/ 50 mg (w/ dapsone 100 mg) daily for 12 mth. Erythema nodosum leprosum (Type 2) Treatment depends on severity. 100-200 mg/day for up to 3 mth. Doses >200 mg/day are not recommended. Gradually taper the dose to 100 mg/day as soon as the reactive episode is controlled. Dapsone-resistant leprosy 100 mg/day w/ 1 or more other antileprosy drugs for 3 yr, then continue as a monotherapy at 100 mg/day.

Contraindication ::

Hypersensitivity. Lactation.

Drug Precautions ::

Pregnancy. Patients with GI symptoms.

Drug Side Effects ::

Red-brownish black discolouration of skin especially areas exposed to sunlight, hair, sweat, sputum, urine, faeces. Rash, pruritus, photosensitivity, diarrhoea, nausea, abdominal pain, vomiting, weight loss, headache, drowsiness, dizziness, taste disorders, dryness of the skin, ichthyosis, decreased tear and sweat production. Potentially Fatal: Crystal depletion in the wall of small bowel mesenteric lymph nodes, liver and spleen. Severe abdominal symptoms including bowel obstruction, GI bleeding and splenic infarction.

Pregnancy category ::
Pregnancy category

3

Drug Mode of Action ::  

Clofazamine inhibits mycobacterial growth by binding preferentially to mycobacterial DNA. It also has some anti-inflammatory activity.

Drug Interactions ::

Dapsone Concomitant use of dapsone and clofazimine does not have a clinically important effect on dapsone pharmacokinetics. Some evidence suggests dapsone may decrease or nullify some anti-inflammatory effects of clofazimine and theoretically might adversely affect clofazimine’s efficacy in patients with ENL reactions; several borderline leprosy and lepromatous leprosy patients with severe, recurrent ENL reactions reportedly required higher clofazimine dosage to control these reactions when dapsone therapy was given concomitantly than when clofazimine was given alone. Isoniazid Possible increased clofazimine plasma and urine concentrations and decreased clofazimine skin concentrations. Rifampin Although one study indicated that concomitant use of clofazimine in leprosy patients receiving rifampin alone or in conjunction with dapsone may decrease plasma concentrations and AUC of rifampin, concomitant use of clofazimine in another study in lepromatous leprosy patients receiving dapsone (100 mg daily) and rifampin (600 mg daily) did not affect rifampin pharmacokinetics.

 

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