The Brand Name ISOS Has Generic Salt :: Streptomycin 

ISOS  Is From Company Neon Priced :: Rs. 15

ISOS have Streptomycin is comes under Sub class Aminoglycosides of  Main Class Anti Infectives

Main Medicine Class:: Anti Infectives  Sub Medicine Class :: Aminoglycosides 

Indications for Drugs ::

Tuberculosis, Bacterial endocarditis, Plague, Tularaemia, Brucellosis

Drug Dose ::

Adult: IM Tuberculosis 15 mg/kg/day. Max: 1 g/day. For intermittent therapy: 25-30 mg/kg/day 2-3 times/wk. Max: 1.5 g/dose. Child: 20-40 mg/kg (max: 1 g) daily or 25-30 mg/kg (max: 1.5 g) 2-3 times wkly. Elderly: >60 kg: Dosage reduction is required. Mycobacterium avium complex infections As adjunct w/ macrolide, rifamycin and ethambutol: 15 mg/kg 3 times/wk for the 1st 2-3 mth for severe disease. Bacterial endocarditis W/ penicillin: Streptococcal endocarditis: 1 g twice daily for the 1st wk, 500 mg twice daily for the 2nd wk; Enterococcal endocarditis: 1 g twice daily for 2 wk, then 500 mg twice daily for 4 wk. Terminate therapy if ototoxicity occurs. Child: To be used concurrently with penicillin. Enterococcal endocarditis: 20-30 mg/kg daily given in 2 divided doses. Recommended treatment duration: 4-6 wk for patients native valve endocarditis and at least 6 wk for patients with prosthetic valve or other prosthetic cardiac material. Brucellosis 1 g/day for 14-21 days, w/ oral doxycyline for 6 wk. Plague 2 g daily for at least 10 days. Tularaemia 1-2 g/day in divided doses for 7-14 days and until the patient is afebrile for 5-7 days. Child: 15 mg/kg bid (max: 2 g daily) for at least 10-14 days. Renal impairment: Modification in dose or dosing interval may be required. CrCl (ml/min) 10-50 Dosing interval: Every 24-72 hr. <10 Dosing interval: Every 72-96 hr. Contraindication ::

Pregnancy; hypersensitivity.

Drug Precautions ::

Renal impairment. Lactation. Avoid topical and inhalational streptomycin. Regular audiometric tests are recommended for prolnoged therapy. Monitor renal function. Increased risk of neurotoxic effects when used in renally impaired patients. Neurotoxicity may cause respiratory paralysis especially if streptomycin is given soon after the use of anaesthesia or muscle relaxants.

Drug Side Effects ::

Giddiness, vertigo, tinnitus, ataxia, hypersensitivity reactions, ototoxicity and nephrotoxicity. Potentially Fatal: Anaphylactic shock, aplastic anaemia and agranulocytosis. Stevens-Johnson syndrome and toxic epidermal necrolysis.

Pregnancy category ::

4

Drug Mode of Action ::  

Streptomycin is bactericidal which inhibits bacterial protein synthesis. Susceptible organisms include Mycobacterium tuberculosis, Pasteurella pestis, P.tularensis, Brucella, H.influenzae, H.ducreyi, Klebsiella pneumonia, Escherichia coli, Proteus spp., Aerobacter aerogenes, Streptococcus faecalis, and Streptococcus viridans.

Drug Interactions ::

H1-receptor blockers may mask early signs of ototoxicity. May reduce excretion of zalcitabine. May inhibit ?-galactosidase activity. Potentially Fatal: Potentiates nephrotoxicity produced by other aminoglycosides, vancomycin and some cephalosporins. Potentiates ototoxicity produced by other aminoglycosides, ethacrynic acid, mannitol, furosemide and other diuretics.