The Brand Name RELBOVIN Has Generic Salt :: Vinorelbine
RELBOVIN Is From Company MIRACALUS Priced :: Rs. 2575.00/10684.00
RELBOVIN have Vinorelbine is comes under Sub class Anti Neoplastic Agents of Main Class Anti Neoplastic Agents
Main Medicine Class:: Anti Neoplastic Agents Sub Medicine Class :: Anti Neoplastic Agents
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Indications for Drugs ::
Breast cancer, Ovarian cancer, Cervical cancer, Non-small cell lung cancer
Drug Dose ::
Adult: PO Non-small cell lung cancer 60 mg/m2/wk for 3 wk, up to 80 mg/m2/wk depending on neutrophil count. IV Non-small cell lung cancer As single agent: 30 mg/m2/wk. Delay treatment if neutrophil count is <2000 cells/mm3 until recovery. As combination therapy w/ cisplatin: 25-30 mg/m2 every 7 days. Cervical cancer 30 mg/m2/dose on days 1 and 8 of a 21-day treatment cycle. Breast cancer; Ovarian cancer 25 mg/m2/dose every 7 days. Contraindication ::
Hypersensitivity to vinorelbine or other vinca alkaloids; severe current or recent infection (within last 2 wk); neutropenia; thrombocytopenia; severe hepatic impairment. Intrathecal admin. Do not give concomitantly with radiotherapy if liver is in treatment field. Pregnancy, lactation.
Drug Precautions ::
Hepatic impairment. Compromised bone marrow reserve due to prior irradiation or chemotherapy; recovering marrow function from the effects of previous chemotherapy. Prior radiation therapy; past history or pre-existing neuropathy. CBC with differentials to be monitored prior to admin of subsequent doses. Delay subsequent doses, if neutrophil count < 2000 cells/mm3. Each admin to be followed by at least 250 ml of normal saline to flush the vein. Avoid extravasation. If extravasation occurs, stop infusion immediately, and flush the vein with normal saline solution; admin the remaining solution in another vein. Do not father a child during and up to six mth after treatment and females of childbearing potential to use effective method of contraception during treatment and three mth thereafter. When admin orally, capsules must be swallowed whole with water and not chewed or sucked. Drug Side Effects ::
Neurotoxicity, peripheral paraesthesia, loss of deep tendon reflexes, abdominal pain, severe constipation, diarrhoea, alopecia, severe local irritation. Dose limiting granulocytopenia, leukopenia and anaemia. Intestinal obstruction, paralytic ileus, nausea, vomitinh, increased in LFT, chest pain, fatigue. Local pain and thrombophlebitis with repeated Inj.
Pregnancy category ::
Drug Mode of Action ::
Vinorelbine, a semisynthetic vinblastine derivative, binds to tubulin and inhibits microtubule formation. This disrupts the formation of the mitotic spindle thereby arresting the cell at metaphase.
Drug Interactions ::
Increased risk of granulocytopenia with cisplatin. Increased risk of neurotoxicity with paclitaxel, itraconazole, ketoconazole. Increased radiosensitising effects with prior or concomitant radiation therapy. Increased pulmonary toxicity with mitomycin. Increased myelotoxicity with zidovudine. Earlier onset and/or an increased severity of side effects with CYP3A inhibitors. Possible increase in vincristine levels with aprepitant. Possible infection with live vaccines.