Diabetic nephropathy (DN) Renal Long-Term complications of DM (Diabetes Mellitus) Diabetic nephropathy (DN) is responsible for high morbidity and mortality. DN is associated with diabetic retinopathy and hyperglycemia. DN is due to the effect of growth factors, Angiotensin Il, endothelin, AGEs. A high body mass index (BMI) has been associated...
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Chronic Long-Term Ophthalmologic Complications of DM (Diabetes Mellitus) Blindness – occurs due to progressive diabetic Retinopathy and macular oedema. Diabetic retinopathy may be non-proliferative and proliferative. Diabetic retinopathy (DR) is one of the most important causes of visual loss worldwide, and is the principal cause of impaired vision in patients...
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Diabetes mellitus Overview Types Causes,Symptoms with Diagnosis Diabetes mellitus is a group of metabolic disorders with hyperglycemia. Glucose intolerance is characterized by hyperglycemia resulting from defects in glucose and fat metabolism. Overt diabetes is classified as type 1 (T1DM), type 2 (T2DM), and gestational (GDM) A chronic metabolic disorder marked...
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INSULIN RESISTANCE SYNDROMES or Syndrome X Overview (metabolic syndrome)- consists of : Insulin resistance Hypertension Dyslipidemias Obesity – central Endothelial dysfunction Accelerated cardiovascular disease. The co-occurrence of metabolic risk factors for both type 2 diabetes and CVD (abdominal obesity, hyperglycemia, dyslipidemias, and hypertension) suggested the existence of a “metabolic syndrome” ...
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ACUTE COMPLICATIONS OF DIABETES MELLITUS (DKA) DKA is characterized by the triad of hyperglycemia, anion gap metabolic acidosis, and ketonemia. Metabolic acidosis is often the major finding. The serum glucose concentration is usually greater than 500 mg/dL (27.8 mmol/L) and less than 800 mg/dL (44.4 mmol/L) . However, serum glucose...
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HYPERGLYCEMIC HYPEROSMOLAR STATE (HHS) hyperosmolar hyperglycemic state (HHS, also known as nonketotic hyperglycemia) and Diabetic ketoacidosis (DKA) are of the most serious acute complications of diabetes. hyperosmolar hyperglycemic state (HHS, also called nonketotic hyperglycemia) In HHS, there is little or no ketoacid accumulation, the serum glucose concentration frequently exceeds 1000...
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CHRONIC COMPLICATIONS OF DIABETES MELLITUS COMMON DISEASES DUE TO DM HYPERGLYCEMIA AND MICROVASCULAR DISEASE — Hyperglycemia is an important risk factor for the development of microvascular disease in patients with type 2 diabetes, as it is in patients with type 1 diabetes. Chronic Long-term complications result in morbidity and mortality. Children...
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DISORDERS OF GROWTH AND DEVELOPMENT Growth is dependent on GH, IGF, sex steroids, thyroid hormones, paracrine growth factors and cytokines. Growth also requires caloric energy, amino acids, vitamins and trace metals. Short stature results due to intrinsic and extrinsic factors which impair growth. Growth GHD Causes may be : Most common...
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Diabetes insipidus (DI) Disorders of Neurohypophysis The neurohypophysis or posterior pituitary gland is made up of nerve tissues originating in supraoptic and paraventricular nuclei of hypothalamus. It produces 2 hormones: 1. AVP or arginine vasopressin, also known as antidiuretic hormone (ADH). 2. Oxytocin AVP acts on renal tubules to absorb...
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Myxedema coma This is a state of hypothyroidism with altered consciousness or coma, sometimes seizures. There may be hypothermia. It is common in the elderly, and precipitated by seda-‘ tives, antidepressants, pneumonia, CHF, MI, cerebrovascular accidents. marked by neurological dysfunction, by respiratory depression, and by lowered body temperature, blood pressure,...
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