Cushing’s Syndrome Causes, Symptoms, Diagnosis, and Treatment Cushing’s disease is a hormone disorder caused by high levels of cortisol in the blood disease in which there is ex­cess ACTH secretion, by pituitary adenomas. Cushing’s syndrome is the signs and symptoms that result from prolonged exposure to excessive glucocorticoid hormones. Cushing’s...
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Diabetes insipidus (DI) Disorders of Neurohypophysis  The neurohypophysis or posterior pituitary gland is made up of nerve tissues originating in su­praoptic and paraventricular nuclei of hypothala­mus. It produces 2 hormones: 1. AVP or arginine vasopressin, also known as antidiuretic hormone (ADH). 2. Oxytocin AVP acts on renal tubules to absorb...
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SIADH or Syndrome of inappropriate ADH (AVP) There is excessive secretion of AVP resulting in pas­sage of decreased volume of highly concentrated urine. There is water retention and decrease in plasma so­dium and plasma osmolarity. It is called dilutional hyponatraemia. It may be asymptomatic or there may be headache, confusion,...
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Thyroid Disorders Thyroid gland produces 2 hormones – Thyroxine or T4 and Triiodothyronine or T3. Functions of the thyroid hormones are: · They help in cell differentiation · Maintain temperature and metabolism. Disorders of Thyroid are due to 1. Overproduction ofthyroid hormone – Thyrotoxi­cosis 2. Decreased production of thyroid hormone...
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What is HYPOTHYROIDISM ? Hypothyroidism is a state of deficient function of the thyroid gland i.e. deficient secretion of thyroid hor­mones. In hypothyroidism normal thyroid hormone levels are maintained by a rise in TSH. This is called subclinical hypothyroidism. Later free T4 level falls and TSH levels rise further. This...
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Myxedema coma  This is a state of hypothyroidism with altered con­sciousness or coma, sometimes seizures. There may be hypothermia. It is common in the elderly, and precipitated by seda-‘ tives, antidepressants, pneumonia, CHF, MI, cere­brovascular accidents. marked by neurological dysfunction, by respiratory depression, and by lowered body temperature, blood pressure,...
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Thyrotoxicosis is a state of thyroid hormone excess. Hyperthyroidism is excessive thyroid function. Hyperthyroidism or thyrotoxicosis defines a spectrum of clinical findings consistent with thyroid hormone excess. Causes of Thyrotoxicosis Primary hyperthyroidism · Grave’s disease · Toxic multinodular goitre · Toxic adenoma · Thyroid carcinoma · Iodine excess (Jod-Basedow phenomenon)...
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Porphyrias The porphyrias are inherited disorders. porphyrias are metabolic disorders caused by altered activities of enzymes within the heme biosynthetic pathway Acute intermittent porphyria: Pyrroloporphyria; neuropsychiatric–abdominal -Aminolevulinic aciduria; neuropsychiatric–abdominal Congenital erythropoietic porphyria: Günther disease; severe dermatologic Hereditary coproporphyria: Neuropsychiatric, occasionally dermatologic Other rare genetic variants reported Porphobilinogen synthetase deficiency: Porphyria...
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Glycogen Storage Diseases Carbohydrate metabolism provides energy for meta­bolic functions of cell. Metabolism of glucose generates ATP by glycolysis and oxidative phosphorylation. Any one of several heritable diseases characterized by the abnormal storage and accumulation of glycogen in the tissues, esp. in the liver Dietary sources of glucose: · Polysaccharide...
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