Adefovir

Details About Generic Salt ::  Adefovir 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

9B. DRUGS FOR HEPATITIS in 9. HEPATOBILIARY SYSTEM
ADEFOVIR
NRTI | ANTI-VIRAL
PK: D: 0.35-0.39 L/kg M: Intestine E: Urine (45%)

Indications & Dose: HEPATITIS WITH HBeAg NEGATIVE PO Adult 10mg OD 1 yr until HBsAg is cleared Child > 12 yr: Same as adult dose | HEPATITIS WITH HBeAg POSITIVE Chronic PO Adult 10mg OD >1 yr until HBeAg seroconversion and undetectable serum HBV DNA, continue therapy > 6 months after HBeAg seroconversion Child > 12 yr: Same as adult dose

Contra: Hypersensitivity

Precautions: Lactic acidosis, renal/hepatic impairment, elderly, children

ADR: Serious: hematuria, renal dysfunction, severe hepatomegaly, pneumonia, Others: headache, abdominal pain, nausea, diarrhea, vomiting, rash

DDI: Serious Tacrolimus/Ciclosporin enhances nephrotoxicity, Saquinavir/Delavirdine levels are reduced

Diet: With/without food

Monitor: HIV status, SeCr, LFTs, HBeAg & anti-HBe