Carbimazole

Details About Generic Salt ::  Carbimazole 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Thyroid , Anti Thyroid Drugs

8A. THYROID & ANTI-THYROID DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
CARBIMAZOLE
THIOUREA | ANTI-THYROID DRUG
PK: A: Rapid D: Extensive M: Hepatic E: Urine

Indications & Dose: BLOCKING-REPLACEMENT REGIMEN PO Adult 20-60mg/day with supplemental levothyroxine | GRAVES DISEASE PO Adult Initially 15-40mg/day in divided doses max 60mg/day MD 5-15mg/day as single dose Child <12 yr: Initially 250µg TID max 60mg daily, 12-18 yr: Initially 10mg TID | HYPERTHYROIDISM PO Adult Initially 15-40mg/day in divided doses max 60mg/day MD 5-15mg/day as single dose Child <12 yr: Initially 250µg TID max 60mg daily, 12-18 yr: Initially 10mg TID | PREPARATION FOR THYROIDECTOMY PO Adult Initially 15-40mg/day in divided doses max 60mg/day MD 5-15mg/day as single dose Child <12 yr: Initially 250µg TID max 60mg daily, 12-18 yr: Initially 10mg TIDAs an adjunct to radio-iodine therapy

Contra: Hypersensitivity

Precautions: Hepatic impairment, neutropenia

ADR: Serious: vasculitis, nephritis, Bone-marrow depression, agranulocytosis, jaundice, lupus like syndrome, Others: Myopathy, myalgia, nausea, vomiting, gastric discomfort, headache, arthralgia, pruritus

DDI: Serious Prednisolone clearance increases, Digoxin levels reduces

Monitor: CBC, LFTs, Creatine phosphokinase, BUN

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