Details About Generic Salt ::  Triamter

Main Medicine Class:: Potassium-sparing diuretic   

(try-AM-tur-een)

Dyrenium

Class: Potassium-sparing diuretic

Drugs Class ::

 Action Interferes with sodium reabsorption at distal renal tubule, resulting in increased excretion of sodium and water and decreased excretion of potassium.

Indications for Drugs ::

 Indications Treatment of edema associated with CHF, hepatic cirrhosis and nephrotic syndrome; treatment of steroid-induced edema, idiopathic edema and edema caused by secondary hyperaldosteronism; management of hypertension in patient with diuretic-induced hypokalemia or at risk of hypokalemia.

Drug Dose ::

 Route/Dosage

ADULTS: PO 100 mg bid after meals (maximum 300 mg/day). CHILDREN: PO 2–4 mg/kg/day given in one dose or 2 divided doses (maximum 300 mg/day).

Contraindication ::

 Contraindications Treatment with spironolactone or amiloride; anuria; severe hepatic disease; yperkalemia; severe or progressive kidney disease or dysfunction, with exception of nephrosis.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Undetermined. Adult-onset diabetes mellitus: Blood glucose levels may be increased; dosage adjustments of hypoglycemic agents may be needed. Concurrent diuretic therapy: Dosage reduction may be necessary. Electrolyte imbalances and BUN increase: Hyperkalemia (serum potassium > 5.5 mEq/l), hyponatremia, hyperchloremia and increases in BUN may occur. Monitor serum electrolytes and BUN levels. Hematologic effects: Triamterene is weak folic acid antagonist and may contribute to appearance of megaloblastosis. Metabolic acidosis: May decrease alkali reserve with possibility of metabolic acidosis. Renal impairment: Use drug with caution; monitor renal function. Renal stones: Triamterene has been found in renal stones. Use drug with caution in patients with history of stone formation.

Drug Side Effects ::

 Adverse Reactions

CV: Hypotension. CNS: Weakness; fatigue; dizziness; headache. DERM: Photosensitivity; rash. GI: Diarrhea; nausea; vomiting; dry mouth. GU: Azotemia; elevated BUN and creatinine; renal stones; bluish discoloration to urine; interstitial nephritis. HEPA: Jaundice; liver enzyme abnormalities. HEMA: Thrombocytopenia; megaloblastic anemia. META: Hyponatremia; hyperchloremic metabolic acidosis; hyperkalemia. OTHER: Anaphylaxis; muscle cramps.

Drug Mode of Action ::  

 Action Interferes with sodium reabsorption at distal renal tubule, resulting in increased excretion of sodium and water and decreased excretion of potassium.

Drug Interactions ::

 Interactions

ACE inhibitors: May result in severely elevated serum potassium levels. Indomethacin: May cause rapid progression into acute renal failure. Potassium preparations and salt substitutes: May severely increase serum potassium levels, possibly resulting in cardiac arrhythmias or cardiac arrest. Do not take with potassium preparations.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Assess renal status, BUN and creatinine levels and fluid and electrolyte status.
• Assess I&O, body weight and hydration status.
• Assess lung sounds and peripheral edema.
• Assess vital signs, especially BP.
• Institute safety precautions to prevent falls, particularly with initial doses.
• Monitor for signs and symptoms of hyperkalemia, especially with diabetic patients.
• Monitor for signs and symptoms of side effects, ie, hyperkalemia, GI disturbances, weakness, dizziness, unusual bleeding or bruising.
• Monitor patient for signs of metabolic acidosis; hyperventilation, drowsiness, restlessness.

Drug Storage/Management ::

 Administration/Storage

• Administer after meals.
• Administer once daily dose in morning to avoid disturbing sleep.
• Open capsules and mix with food or fluids if appropriate for patient needs.
• Store at room temperature in tight, light resistant container.

Drug Notes ::

 Patient/Family Education

• Tell patient to avoid salt substitute and limit potassium-rich foods.
• Inform patients taking antihypertensives that additive effects are possible; identify signs and symptoms of hypotension and precautions to be taken.
• Advise patient that medication may cause urine to become blue tinged.
• Explain potential GI side effects and to take medication after meals.
• Tell patient that drug may cause weakness, headache, nausea, vomiting or dry mouth and to notify physician if they become severe or persistent.
• Instruct patient to report these symptoms to physician: fever, sore throat, mouth sores or unusual bleeding or bruising.
• Caution patient to avoid intake of alcoholic beverages or other CNS depressants.
• Advise patient to use caution while driving or performing other tasks requiring mental alertness.
• Caution patient to avoid exposure to sunlight or ultraviolet light and to use sunscreen or wear protective clothing to prevent photosensitivity reaction.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.