Carboplatin

Details About Generic Salt ::  Carboplatin 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
CARBOPLATIN
ALKYLATING AGENT | ANTI-NEOPLASTIC
PK: D: 16 L (Vd) M: Hepatic E: Urine

Indications & Dose: ADVANCED OVARIAN CANCER Combination therapy IV Adult 300mg/m2 as inf over 15-60min q4wk with cyclophosphamide | Mono therapy IV Adult 360mg/m2 as inf over 15-60min q4wk

Contra: History of severe allergic reaction, severe bone marrow depression/significant bleeding, renal/hearing impairment, contact with skin & eyes, acute infect

Precautions: Renal impairment, elder, debilitated patients

ADR: Serious: Electrolyte distubance, myelosuppression, blood disorders, AST/alkaline phosphatase increased, Clcr decreased, BUN increased, Hypersensitivity/allergic reaction, neurotoxicity, hemorrhagic complications, peripheral neuropathy, visual disturbance, ototoxicity, infect, Others: alopecia, constipation, diarrhea, weakness, vomiting, abdominal pain, nausea, Pain

DDI: Serious Etoposide clearance modestly reduces by drug, Warfarin effects increases, Paclitaxel leads to neurotoxicity

Monitor: CBC with differential & platelet count, serum electrolytes, SeCr & BUN, Clcr, LFTs

Related Posts:
You May Also Like::
Tagged with