Clomifene

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Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

11B. DRUGS FOR ERECTILE DYSFUNCTION/LIBIDO/INFERTILITY in 11. REPRODUCTIVE SYSTEM
CLOMIFENE
CHLOROTRIANISENE DERIVATIVE | OVULATION STIMULANT
PK: A: Rapid M: Hepatic E: Bile

Indications & Dose: OVULATORY INFERTILITY PO Adult 50mg/day for 5 days, starting within 5 days of onset of menstruation, preferably on 2nd day or at any time if cycles have ceased. If ovulation does not occur a second course of 100mg/day for 5 days may be used

Contra: Hypersensitivity, abnormal uterine bleeding, uncontrolled thyroid or adrenal dysfunction, hepatic disease, ovarian cysts, hormone dependent tumours, patients with pre-existing mental depression or thrombophlebitis

Precautions: Ovarian hyperstimulation & visual disturbances syndrome, polycystic ovarian syndrome, uterine fibroids

ADR: Serious: Ovarian hyperstimulation, visual disturbances, convulsions, Others: weight gain, rash, dizziness, hair loss, Hot flushes, abdominal discomfort, nausea, vomiting, depression, insomnia, breast tenderness, headache, intermenstrual spotting, menorrhagia, endometriosis

Monitor: Basal body temperature, Serum progesterone, urinary luteinizing hormone, follicular growth & endometrial thickness, pregnancy test prior to repeat courses