Details About Generic Salt ::  Amobarb1

Main Medicine Class:: Sedative and hypnotic barbiturate   

Tuinal 100 mg Pulvules, Tuinal 200 mg Pulvules,  Tuinal
Class: Sedative and hypnotic barbiturate


Drugs Class ::

 Action Depresses sensory cortex, decreases motor activity, alters cerebellar function and produces drowsiness, sedation and hypnosis.

Indications for Drugs ::

 Indications Treatment of short-term insomnia; induction of preanesthetic sedation.

Drug Dose ::


ADULTS: PO 1 capsule (50 mg/50 mg or 100 mg/100 mg) at bedtime or 1 hr before surgery.

Contraindication ::

 Contraindications Hypersensitivity to barbiturates; history of addiction to sedative-hypnotic drugs; history of porphyria; severe liver impairment; respiratory disease with dyspnea; nephrosis.

Drug Precautions ::


Pregnancy: Category D. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Elderly: Reduce dosage. Drug dependence: Tolerance or psychologic and physical dependence may occur with continued use. Renal or hepatic impairment: Use with caution; reduce dosage.


Drug Side Effects ::

 Adverse Reactions

CV: Bradycardia; hypotension; syncope. CNS: Drowsiness; agitation; confusion; headache; hyperkinesia; ataxia; CNS depression; paradoxical excitement; nightmares; psychiatric disturbances; hallucinations; insomnia; dizziness. GI: Nausea; vomiting; constipation. HEMA: Blood dyscrasias (agranulocytosis, thrombocytopenia). HEPA: Liver damage. RESP: Hypoventilation; apnea; laryngospasm; bronchospasm. OTHER: Hypersensitivity reactions (eg, angioedema, rashes, exfoliative dermatitis); fever; injection site reactions (eg, local pain, thrombophlebitis).

Drug Mode of Action ::  

 Action Depresses sensory cortex, decreases motor activity, alters cerebellar function and produces drowsiness, sedation and hypnosis.

Drug Interactions ::


Alcohol, CNS depressants: Depressant effects of these drugs may be enhanced. Anticoagulants, beta-blockers, calcium channel blockers (eg, Verapamil), theophyllines: Activity of these drugs may be reduced. Anticonvulsants: Serum concentrations of carbamazepine, valproic acid and succinimides may be reduced. Valproic acid may increase barbiturate serum levels. Corticosteroids: Effectiveness may be reduced. Estrogens, estrogen-containing oral contraceptives: Effectiveness may be reduced.

Drug Assesment ::


  • Obtain patient history, including drug history and any allergies. Note history of drug abuse.
  • Assess patient’s sleep patterns and mental status before beginning therapy and monitor periodically during long-term therapy.
  • Assess vital signs prior to initial dose.
  • Ensure that hepatic function tests have been performed and hematology test results and serum folate and vitamin D levels have been determined before beginning long-term therapy.
  • Darken room, provide quiet environment and offer caffeine-free warm beverage to promote sleep at bedtime.
  • If signs of respiratory depression or overdosage develop, withhold dose and notify physician.
  • Report unexpected responses (particularly in elderly) such as marked excitement, confusion, restlessness, or depression.
  • Implement safety measures to prevent falls, especially in elderly patients.
  Respiratory depression, CNS depression progressing to Cheyne-Stokes respiration, oliguria, tachycardia, hypotension, hypothermia, coma, shock, cessation of electrical activity in brain (extreme overdose)

Drug Storage/Management ::


  • Administer at bedtime or 1 to 2 hr prior to procedure.
  • May be crushed and given mixed with food or fluid.
  • Store at room temperature in tightly closed container.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to avoid intake of alcohol or other CNS depressants (eg, sedatives or tranquilizers).
  • Caution patient to avoid nicotine and caffeine.
  • Advise patient that drug may cause drowsiness, and to avoid driving or performing other activities requiring mental alertness or coordination.
  • Instruct patient to keep medication in daily-dose system or in locked cabinet to avoid accidental overdosage.
  • Teach patient appropriate exercise and stress-reduction techniques to promote rest.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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