Cyclobenzaprine

Details About Generic Salt ::  Cyclobenzaprine 

Main Medicine Class:: #N/A   Sub Medicine Class ::  #N/A

12A. SKELETAL MUSCLE RELAXANTS in 12. MUSCULOSKELETAL DISORDERS & PAIN
CYCLOBENZAPRINE
CENTRALLY ACTING SKELETAL MUSCLE RELAXANT | SKELETAL MUSCLE RELAXANT
PK: A: Completely absorbed M: Hepatic E: Urine, feces

Indications & Dose: MUSCLE SPASM ASSOCIATED WITH MUSCULOSKELETAL CONDITIONS Symptomatic therapy PO Adult Cap(ER): 15mg/day, max 30mg/day. Tab (IR): 5mg TID, may increase up to 10mg TID Child >15 yrs: Tab (IR): 5mg TID, may increase up to 10mg TID Elderly Tab (IR): 5mg, titrate slowly & consider less frequent dosing

Contra: Hypersensitivity, during/within 14 days of MAOIs, moderate to severe hepatic impairment, CHF, hyperthyroidism, acute recovery phase of MI, heart block/conduction disturbances, arrhythmias

Precautions: elderly, hepatic impairment

ADR: Serious: blurred vision, pharyngitis, URTI, Others: drowsiness, dizziness, xerostomia, fatigue, headache, confusion, decreased mental acuity, irritability, nervousness, dyspepsia, abdominal pain, acid regurgitation, constipation, diarrhea, nausea, unpleasant taste, weakness

DDI: Others Fluoxetine and droperidol together causes torsade de pointes & ventricular fibrillation, Methotrimeprazine/CYP1A2 Inhibitors increases Cyclobenzaprine effects, CNS Depressants/Alcohol/MAOIs levels are increase

Monitor: Signs/symptoms of serotonin syndrome

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