Details About Generic Salt ::  Acetohex

Main Medicine Class:: Antidiabetic,sulfonylurea   

(uh-seet-toe-HEX-uh-mide)

Dymelor,  Dimelor

Class: Antidiabetic/sulfonylurea

Drugs Class ::

 Action Decreases blood glucose by stimulating release of insulin from pancreas.

Indications for Drugs ::

 Indications Adjunctive therapy, used with dietary modification, in patients with noninsulin-dependent diabetes mellitus (type II) for lowering blood glucose level.

Drug Dose ::

 Route/Dosage

ADULTS: PO 250 mg to 1.5 g/day. In patients receiving £ 1 g daily, condition can be controlled with once-daily dosage; 1.5 g/day is given bid (maximum 1.5 g/day).

Contraindication ::

 Contraindications Hypersensitivity to sulfonylureas; diabetes complicated by ketoacidosis; sole therapy of insulin-dependent (type I) diabetes mellitus; diabetes complicated by pregnancy.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Insulin is recommended to maintain blood glucose levels during pregnancy. Prolonged severe neonatal hypoglycemia can occur if sulfonylureas are administered at time of delivery. Lactation: Undetermined. Children: Safety and efficacy not established. Elderly or debilitated patients: Particularly susceptible to hypoglycemic effects of drug. Disulfiram-like syndrome: Alcohol may cause facial flushing and breathlessness. Hepatic and renal impairment: Cautious use is necessary. Hypoglycemia: May be difficult to recognize in elderly patients or in patients receiving beta-blockers. Loss of blood glucose control: Stress (eg, fever, surgery) or secondary drug failure may precipitate loss of blood glucose control.

Drug Side Effects ::

 Adverse Reactions

CV: Possible increased risk of cardiovascular mortality as compared with treatment with diet alone. CNS: Dizziness; vertigo. DERM: Allergic skin reactions; eczema; pruritus; erythema; urticaria; morbilliform or maculopapular eruptions, lichenoid reactions; photosensitivity. EENT: Tinnitus. Nausea; epigastric fullness; heartburn; cholestatic jaundice (rare, discontinue drug if this occurs). GU: Mild diuresis. HEMA: Leukopenia; thrombocytopenia; aplastic anemia; agranulocytosis; hemolytic anemia; pancytopenia. HEPA: Hepatic porphyria. META: Hypoglycemia. OTHER: Disulfiram-like reaction; weakness; paresthesia, fatigue; malaise.

Drug Mode of Action ::  

 Action Decreases blood glucose by stimulating release of insulin from pancreas.

Drug Interactions ::

 Interactions

Androgens, chloramphenicol, clofibrate, fenfluramine, H₂ antagonists, MAO inhibitors, phenylbutazone, probenecid, salicylates, sulfonamides: Hypoglycemic effect may be increased. Diazoxide, rifampin, thiazide diuretics: Hypoglycemic effect of acetohexamide may be decreased.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Assess condition of patient’s feet, and routinely perform foot care.
• Note baseline liver function, BUN, and creatinine. Monitor for elevated levels.
• Assess current blood glucose levels. Observe patient for signs of hyperglycemia (eg, frequent urination, thirst, weakness, weight loss, ketoacidosis) and hypoglycemia (eg, tingling of lips and tongue, nausea, diminished cerebral function [eg, lethargy, confusion], tachycardia, sweating, convulsions, coma). Have oral glucose or carbohydrates and IV glucose available.
• Monitor liver and renal function regularly.
• Monitor effectiveness of diabetes control through individualized treatment plan, including diet, daily blood glucose levels, medication, and exercise.

Drug Storage/Management ::

 Administration/Storage

• Administer at same time each day, with food if desired.
• Do not give < 1.5 g/day.
• For amounts < 1 g, administer in divided doses before morning and evening meals.
• Store tablets in tightly-closed container at room temperature.

Drug Notes ::

 Patient/Family Education

• Advise patient that drug may be taken with food if nausea occurs.
• Review symptoms of hypoglycemia and hyperglycemia.
• Emphasize importance of wearing Medi-Alert bracelet at all times.
• Instruct patient to call physician if any of the following symptoms occur: Nausea, vomiting, heartburn, diarrhea, fever, sore throat, rash, itching, weakness, unusual bruising, bleeding.
• Caution patient about the following possible effects of alcohol intake: Flushing, weakness, dizziness, tingling sensation, headache.
• Caution patient to avoid exposure to sunlight, and to use sunscreen or wear protective clothing to avoid photosensitivity reaction.
• Advise patient not to take any otc medications without consulting physician.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.