Details About Generic Salt ::  Benztrop

Main Medicine Class:: Antiparkinson,Anticholinergic   

(BENZ-troe-peen MEH-sih-LATE)
Cogentin,  Apo-Benztropine, PMS Benztropine
Class: Antiparkinson/Anticholinergic


Drugs Class ::

 Action Thought to act by competitively antagonizing acetylcholine receptors in corpus striatum to restore neuromuscular balance.

Indications for Drugs ::

 Indications Treatment of all forms of parkinsonism; control of extrapyramidal disorders (except tardive dyskinesia) due to neuroleptic drugs.

Drug Dose ::



ADULTS: PO 1 to 2 mg/day; range: 0.5 to 6 mg. Individualize dosage. IDIOPATHIC PARKINSONISM: ADULTS: PO Initially 0.5 to 1 mg at bedtime; 4 to 6 mg/day may be required. POSTENCEPHALITIC PARKINSONISM: ADULTS: PO 2 mg/day in 1 or more doses; some patients may require initial dose of 0.5 mg.

Drug-Induced Extrapyramidal Disorders

ADULTS: 1 to 4 mg qd or bid.

Acute Dystonic Reactions

ADULTS: PO/IM/IV Initial dose: IM/IV 1 to 2 mg; then PO 1 to 2 mg bid.

Contraindication ::

 Contraindications Angleclosure glaucoma; myasthenia gravis; pyloric or duodenal obstruction; stenosing peptic ulcer; prostatic hypertrophy or bladder neck obstructions; megacolon; tardive dyskinesia; children < 3 yr old.

Drug Precautions ::


Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established Elderly patients: Patients > 60 yr may have increased side effects; dosage reduction and observation may be needed. Special risk patients: Use with caution in patients with glaucoma, prostatic hypertrophy, epilepsy, cardiac arrhythmias, hypertension, hypotension, tendency toward urinary retention, liver or kidney disorders, obstructive disease of GI or GU tract, tachycardia or those who are taking other drugs with anticholinergic activity. Heat illness: Fatal hyperthermia has occurred. Use with caution during hot weather. Ophthalmic: Narrow-angle glaucoma may occur. Tardive dyskinesia: May aggravate tardive dyskinesia.


Drug Side Effects ::

 Adverse Reactions

CV: Tachycardia; bradycardia. CNS: Toxic psychosis including confusion, disorientation, memory impairment, visual hallucinations; exacerbation of pre-existing psychosis; nervousness; depression; finger numbness. DERM: Skin rash. EENT: Blurred vision; dilated pupils; narrow-angle glaucoma. GI: Paralytic ileus; constipation; nausea; vomiting; dry mouth. GU: Urinary retention; dysuria. OTHER: Heat stroke; hyperthermia; fever; weakness; inability to move particular muscle groups.

Drug Mode of Action ::  

 Action Thought to act by competitively antagonizing acetylcholine receptors in corpus striatum to restore neuromuscular balance.

Drug Interactions ::


Amantadine: May increase anticholinergic effects. Digoxin: May increase digoxin serum levels, especially with slow-dissolution oral digoxin tablets. Haloperidol: May worsen schizophrenic symptoms; may decrease haloperidol serum levels; tardive dyskinesia may develop. Phenothiazines: May decrease action of phenothiazines. May increase incidence of anticholinergic effects.

Drug Assesment ::


  • Obtain patient history, including drug history and any allergies. Note glaucoma, urinary retention, prostatic hypertrophy, or constipation.
  • Monitor vital signs and I&O for anticholinergic side effects (eg, hypotension, urinary retention).
  • Monitor patient for reduction of rigidity and decrease in tremors during therapy.
  • Monitor frequency of bowel movements. Patient may need stool softener.
  Circulatory collapse, cardiac arrest, respiratory depression, CNS depression or stimulation, shock, coma, stupor, seizures, convulsions, ataxia, anxiety, incoherence, hyperactivity, smelly breath, decreased bowel sounds, dilated and sluggish pupils

Drug Storage/Management ::


  • When given PO, administer with food to prevent GI irritation.
  • If patient has difficulty swallowing, tablet may be crushed.
  • May be given IM or IV in acute dystonic reaction. However, because onset and efficacy are equivalent for IM and IV route, IV administration is usually unnecessary.
  • Store in a dry place in tightly closed, light-resistant container.

Drug Notes ::

 Patient/Family Education

  • Explain that full effectiveness of drug may not occur for 2 to 3 days after initiation of drug therapy. Explain that doses will be tapered gradually before stopping.
  • Advise patient that increasing fluid intake will help decrease dry mouth and constipation.
  • Instruct patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
  • Warn patient to pay particular attention to dental hygiene because of problems associated with decreased salivation.
  • Tell patient that stool softeners may be used if constipation occurs.
  • Warn patient to drink plenty of fluids and take precautions against hyperthermia in hot weather.
  • Tell patient that vision may be blurry during the first 2 to 3 wk of treatment.
  • Advise patient that wearing sunglasses outdoors will help to minimize photophobia.
  • Instruct patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.
  • Advise patient to avoid intake of alcoholic beverages or other CNS depressants.
  • Instruct patient to obtain periodic eye examinations during long-term treatment to monitor for glaucoma.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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