Details About Generic Salt ::  Ceftriax

Main Medicine Class:: Antibiotic,cephalosporin   

(SEFF-TRY-AXE-own SO-dee-uhm)

Rocephin

Class: Antibiotic/cephalosporin

Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of infections of lower respiratory tract, skin and skin structures, bone and joint, urinary tract; treatment of pelvic inflammatory disease, intra-abdominal infections, gonorrhea, meningitis and septicemia due to susceptible microorganisms; preoperative prophylaxis. Unlabeled use(s): Treatment of Lyme disease in patients refractory to penicillin G.

Drug Dose ::

 Route/Dosage

Infection

ADULTS: IV/IM 1–2 g/day or in equally divided doses q 12 hr (maximum 4 g/day). CHILDREN: IV/IM 50–75 mg/kg/day in equally divided doses q 12 hr (maximum 2 g/day).

Uncomplicated Gonococcal Infections

ADULTS: IM 250 mg as single dose.

Surgical Prophylaxis

ADULTS: IV/IM 1 g as single dose ½-2 hr before surgery.

Pediatric Meningitis

CHILDREN: IV/IM 75 mg/kg as loading dose then 100 mg/kg/day in divided doses q 12 hr (maximum 4 g/day).

Contraindication ::

 Contraindications Hypersensitivity to cephalosporins.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Children: Cephalosporins may accumulate in neonates. Hypersensitivity: Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients due to possible cross-reactivity. Pseudomembranous colitis: Should be considered in patients in whom diarrhea develops. Superinfection: May result in bacterial or fungal over-growth of nonsusceptible micro-organisms.

Drug Side Effects ::

 Adverse Reactions

GI: Nausea; vomiting; diarrhea; colitis, including pseudomembranous colitis. GU: Renal dysfunction; pyuria; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy, urinary casts. HEMA: Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; decreased platelet function; anemia; aplastic anemia; hemorrhage. HEPA: Hepatic dysfunction; jaundice; abnormal liver function test results. OTHER: Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness–like reactions (eg, skin rashes, polyarthritis; arthralgia, fever); phlebitis, thrombophlebitis and pain at injection site.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::

 Interactions

Aminoglycosides: Increased risk of nephrotoxicity. INCOMPATIBILITIES: Other antimicrobial drugs.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Note allergy to cephalosporins or penicillins.
• Obtain specimens for culture and sensitivity before beginning therapy and periodically during treatment.
• Monitor renal function carefully during treatment.
• Monitor for signs of infection, especially fever, and for positive response to antibiotic therapy.
• Assess for signs and symptoms of anaphylaxis (shortness of breath, wheezing, laryngeal spasm). Have resuscitation equipment available.
• Assess for signs of superinfection, such as vaginitis or stomatitis.
• Assess for diarrhea with blood or pus, which may be symptom of pseudomembranous colitis. Symptoms may occur after antibiotic treatment.
• Monitor for coagulation abnormalities. Elevated prothrombin time or abnormal platelet count may occur. If bleeding occurs and PT is prolonged, vitamin K may be indicated.
• Monitor IV site for infiltration, infection, thrombophlebitis and bleeding.

Drug Storage/Management ::

 Administration/Storage

• Reconstituted solution should be light yellow to amber. Do not administer if solution is cloudy or precipitate is present.
• When giving by IM route, inject deeply into large muscle (eg, upper outer quadrant of gluteus muscle or lateral thigh); massage well.
• When giving by IV route, administer slowly over 3–5 min. Change IV sites q 48–72 hr.
• Reconstituted drug should not be mixed with other antibiotics.
• For piggyback infusion, reconstituted solution may be diluted with D5W or 0.9% Sodium Chloride infused over 30–60 min.
• For preoperative surgical prophylaxis, administer ceftriaxone 50–120 min before surgical incision.
• When reconstituted with 250 ml of diluent, use within 24 hr when stored at room temperature and within 3 days if refrigerated.
• When reconstituted with 100 ml of Sterile Water for Injection, 0.9% Sodium Chloride or 5% Dextrose, use within 3 days when stored at room temperature and within 10 days if refrigerated.
• Completely thaw frozen preparations at room temperature before use; do not refreeze.
• Store sterile powder at room temperature and protect from heat or light.

Drug Notes ::

 Patient/Family Education

• Remind patient to check body temperature daily. If fever persists for more than a few days or if high fever (> 102°F) or shaking chills are noted, physician should be notified immediately.
• Advise patient to maintain normal fluid intake while using this medication.
• Instruct diabetic patient to use enzyme-based tests (eg, Clinistix, Testape) for monitoring urine glucose because drug may give false results with other tests.
• Instruct patient to report these symptoms to physician: nausea, vomiting, diarrhea, skin rash, hives, sore throat, bruising, bleeding, muscle or joint pain.
• Advise patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.
• Warn patient that diarrhea that contains blood or pus may be a sign of serious disorders. Tell patient to seek medical care and not to treat at home.
• Instruct patient to seek emergency care immediately if wheezing or difficulty in breathing occurs.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.