Details About Generic Salt ::  Dobutami

Main Medicine Class:: Vasopressor   

(doe-BYOOT-uh-meen)

Dobutrex

Class: Vasopressor

Drugs Class ::

 Action Stimulates beta₁-receptors in heart, causing more complete and forceful contractions (inotropy) without significantly increasing heart rate or BP.

Indications for Drugs ::

 Indications Treatment of cardiac decompensation caused by organic heart disease or cardiac surgical procedures. Unlabeled use(s): Congenital heart disease in children undergoing diagnostic cardiac catheterization.

Drug Dose ::

 Route/Dosage

ADULTS: IV infusion 2.5 to 10 mcg/kg/min; titrate to desired response; increase in heart rate > 10% may develop in rate > 20 mcg/kg/min; rates up to 40 mcg/kg/min are rarely used. Duration of therapy up to 72 hr without decrease in clinical effectiveness may be used.

Contraindication ::

 Contraindications Idiopathic hypertrophic subaortic stenosis.

Drug Precautions ::

 Precautions

Pregnancy: Safety not established. Lactation: Undetermined. Children: Safety and efficacy not established. Special risk patients: Use with extreme caution after myocardial ischemia. Avoid use in uncorrected hypovolemic states unless used as temporary emergency measure to maintain coronary and cerebral flow. Cardiovascular effects: May greatly increase BP and heart rate, especially with preexisting hypertension. Dose reduction may reverse effects. May precipitate or exacerbate ventricular ectopic activity. Hypokalemia: Mild hypokalemia may occur. Sulfite sensitivity: Use caution in sulfite-sensitive individuals; some preparations contain sodium bisulfite.

Drug Side Effects ::

 Adverse Reactions

CV: Increased systolic BP; increased heart rate; chest pain; increased number of premature ventricular beats. CNS: Headache; tingling sensations; paresthesia. GI: Nausea; vomiting. RESP: Dyspnea. OTHER: Phlebitis; local inflammation after infiltration; leg cramps.

Drug Mode of Action ::  

 Action Stimulates beta₁-receptors in heart, causing more complete and forceful contractions (inotropy) without significantly increasing heart rate or BP.

Drug Interactions ::

 Interactions

Beta-blockers: May antagonize beta receptor-stimulating activity of dobutamine. Furazolidone, methyldopa, rauwolfia alkaloids: Hypertension may result. Guanethidine: May increase pressor response. Halogenated hydrocarbon anesthetics: May increase risk of arrhythmias by sensitizing cardiac tissue to sympathomimetic agents. Tricyclic antidepressants: May potentiate effect of dobutamine; use combination with caution. Incompatibilities: Chemically incompatible with sodium bicarbonate or other alkaline solutions.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Monitor vital signs, ECG, cardiac output, pulmonary capillary wedge pressure, central venous pressure and urinary output carefully throughout infusion.
• Monitor potassium levels to detect possible hypokalemia.
• Monitor patency and placement of IV catheter to reduce risk of extravasation and phlebitis.
• If patient has diabetes, monitor blood glucose level. Report significant increase to physician.

Drug Storage/Management ::

 Administration/Storage

• Administer by IV infusion only. Use electronic infusion device to monitor infusion rate.
• Reconstitution/dilution is done in two stages.
• First, more concentrated solution can be kept under refrigeration for 48 hr or at room temperature for 6 hr.
• Before administration, solution is further diluted to typical concentration of 0.25 to 1 mg/ml (250 to 1000 mcg/ml). Final concentration should not exceed 5 mg/ml. This solution should be used within 24 hr.
• Solution may have pink color, because of slight oxidation, but this effect does not indicate loss of potency.
• Do not freeze solution because crystallization may occur.

Drug Notes ::

 Patient/Family Education

• Instruct patient to report these symptoms to physician: pain or discomfort at IV site, any anginal pain.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.