Details About Generic Salt ::  Isosorbi

Main Medicine Class:: Antianginal   

(EYE-sos-ORE-bide die-NYE-trate)
Dilatrate-SR, Isordil, Isordil Tembids, Isodril Titradose, Sorbitrate,  APO-ISDN, Cedocard-SR
Class: Antianginal


Drugs Class ::

 Action Relaxation of smooth muscle of venous and arterial vasculature.

Indications for Drugs ::

 Indications Treatment and prevention of angina pectoris.

Drug Dose ::


Angina Pectoris

ADULTS: SL (sublingual tablets) 2.5 to 5 mg; PO (chewable tablets) 5 mg; PO (oral tablets) 5 to 40 mg q 6 hr; PO (sustained release tablets) 40 to 80 mg q 8 to 12 hr.

Acute Prophylaxis

ADULTS: PO (sublingual or chewable tablets) 5 to 10 mg q 2 to 3 hr.

Contraindication ::

 Contraindications Hypersensitivity to nitrates; severe anemia; closed-angle glaucoma; orthostatic hypotension; head trauma or cerebral hemorrhage.

Drug Precautions ::


Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Special risk patients: Use with caution in patients with acute MI or CHF. Angina: May aggravate angina caused by hypertrophic cardiomyopathy. Orthostatic hypotension: May occur even with small doses; alcohol accentuates this reaction. Tolerance: Tolerance to vascular and antianginal effects may develop.


Drug Side Effects ::

 Adverse Reactions

CV: Tachycardia; palpitations; hypotension; syncope; arrhythmias. CNS: Headache; apprehension; weakness; vertigo; dizziness; agitation; insomnia. DERM: Cutaneous vasodilation with flushing. EENT: Blurred vision. GI: Nausea; vomiting; diarrhea; dyspepsia. GU: Dysuria; urinary frequency; impotence. HEMA: Methemoglobinemia; hemolytic anemia. RESP: Bronchitis; pneumonia. OTHER: Arthralgia; perspiration; pallor; cold sweat; edema.

Drug Mode of Action ::  

 Action Relaxation of smooth muscle of venous and arterial vasculature.

Drug Interactions ::


Alcohol: Severe hypotension and cardiovascular collapse. Aspirin: Increased nitrate concentration and actions. Dihydroergotamine: Increased systolic blood pressure and decreased antianginal effects.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Monitor for headache, hypotension, tachycardia, decreased pulse rate, heart block, and decreased respiratory rate.
  • Monitor hemoglobin levels.
  Hypotension, tachycardia, flushing, diaphoresis, headache, vertigo, palpitations, visual disturbances, nausea, vomiting, confusion, dyspnea

Drug Storage/Management ::


  • Sublingual tablets should be placed under tongue to dissolve. Do not swallow.
  • Chewable tablets should be chewed and swallowed. Do not crush before administering.
  • Oral dosage forms should be taken on empty stomach with full glass of water.
  • Store at room temperature.

Drug Notes ::

 Patient/Family Education

  • Instruct patient not to chew sublingual tablets. Emphasize need to hold chewable tablets in mouth for 1 to 2 min and then chew thoroughly before swallowing, to allow for absorption.
  • Advise patient not to stop taking medication suddenly; withdrawal syndrome may occur.
  • Instruct patient to notify physician immediately or go to nearest hospital emergency department if chest pain persists or worsens after taking prescribed dose.
  • Advise patient to notify physician if effectiveness of therapy decreases over time; tolerance may develop.
  • Instruct patient to report the following symptoms to physician: Severe or persistent headache, blurred vision, dry mouth, dizziness, flushing.
  • Caution patient to avoid sudden position changes to prevent orthostatic hypotension.
  • Instruct patient to avoid intake of alcoholic beverages or alcohol-containing products.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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