Details About Generic Salt ::  Pemoline

Main Medicine Class:: Psychotherapeutic   

Tablets: 18.75 mg, 37.5 mg, 75 mg
Tablets, chewable: 37.5 mg
Class: Psychotherapeutic


Drugs Class ::

 Action Acts as a CNS stimulant but with minimal sympathomimetic effects; exact mechanism of action unknown.

Indications for Drugs ::

 Indications Treatment of attention-deficit hyperactivity disorder. Unlabeled use(s): Treatment of narcolepsy and excessive daytime sedation.

Drug Dose ::


ADULTS AND CHILDREN 6 YR AND OLDER: PO 37.5 mg/day as a single dose in the morning initially; increase by increments of 18.75 mg weekly until desired response is obtained (max daily dose 112.5 mg/day).

Contraindication ::

 Contraindications Hepatic insufficiency.

Drug Precautions ::


Pregnancy: Category B. Lactation: Undetermined. Children: Safety and efficacy in children younger than 6 yr not established. Drug abuse and dependence: Can occur; use with caution in emotionally unstable patients who may increase the dosage on their own initiative. Hepatic failure: Life-threatening hepatic failure has been associated with pemoline use; therefore, pemoline is not usually considered first-line therapy. Renal impairment: Use with caution in patients with significantly impaired renal function.


Drug Side Effects ::

 Adverse Reactions

CNS: Insomnia; Tourette syndrome; hallucinations; dyskinetic movements of tongue, lips, face, and extremities; abnormal oculomotor function (eg, nystagmus, oculogyric crisis); depression; dizziness; irritability; headache; drowsiness; seizures. DERM: Rash. GI: Anorexia; transient weight loss; stomach ache; nausea. HEPA: Elevated liver enzymes; hepatitis; jaundice. OTHER: Growth suppression.

Drug Mode of Action ::  

 Action Acts as a CNS stimulant but with minimal sympathomimetic effects; exact mechanism of action unknown.

Drug Interactions ::

 Interactions None well documented.

Drug Assesment ::


  • Obtain patient history.
  • Clinically assess for tics and Tourette syndrome in children and their families before use of this drug.
  • Monitor growth of children during treatment, as long-term administration is associated with growth inhibition.
  • Ensure LFTs are performed prior to and periodically during therapy.
  • Assess therapeutic effects of medication. Medication is often interrupted at intervals to determine therapeutic effects and to ascertain if there are sufficient behavioral symptoms present to require continued therapy.
  • Ensure that dosage is decreased gradually following long-term therapy to prevent withdrawal symptoms.
  Vomiting, agitation, tremors, hyperreflexia, muscle twitching, convulsions (followed by coma), euphoria, confusion, hallucinations, delirium, sweating, flushing, headache, high fever, tachycardia, hypertension, dilated pupils

Drug Storage/Management ::


  • Do not administer if LFTs are abnormal.
  • Administer as a single dose each morning and ensure that chewable tablets are completely chewed and swallowed.
  • Administer with caution to emotionally unstable patients. Administration may intensify symptoms of behavior disturbance and thought disorder.
  • Administer with caution to patients with impaired renal function.
  • Store at controlled room temperature (56° to 86°F) in a tight, dry container.

Drug Notes ::

 Patient/Family Education

  • Advise patient that clinical improvement is gradual and benefits may not occur until wk 3 or 4 of administration.
  • Instruct patient to take pemoline as prescribed and not to make up missed doses.
  • Caution patient to avoid taking large doses of caffeine or using other stimulants that could adversely potentiate the effects of pemoline.
  • Instruct patient to take medication in the morning to avoid sleep disturbance. Notify health care provider if problems with sleeping occur.
  • Instruct patient to notify health care provider of adverse reactions; the dosage may need to be reduced or the drug discontinued.
  • Advise patient that medication can cause dizziness or drowsiness and to avoid driving and other tasks requiring mental alertness.
  • Instruct patient not to increase the dose amount or take the medication more frequently because of a high dependence and abuse potential. In addition, psychotic symptoms could occur following long-term misuse of excessive oral doses.
  • Instruct caregiver, patient, or family to be aware of the symptoms of overdose and take immediate and appropriate action, such as notifying a poison control center.
  • Instruct patient to take daily dose in the morning.
  • Advise patient to follow health care provider instructions for LFTs.
  • Advise patient to be alert for signs and symptoms of liver dysfunction (eg, jaundice, anorexia, malaise, GI complaints) and to report them immediately to the health care provider.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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