Details About Generic Salt ::  Ketoconazole 

Main Medicine Class:: Skin   Sub Medicine Class ::  Anti Microbials (Fungal,

also comes under 13I. Anti-Fungals in 13. Anti-Infectives,  
PK: A: Rapid D: Extensive M: Hepatic E: Feces (57%), urine (13%)

Indications & Dose: BLASTOMYCOSIS PO Adult 400mg OD/BID | CANDIDAL/DERMATOPHYTE INFECT OF THE SKIN TP Adult Cream (2%): Apply OD/BID, continued for few days after disappearance of symptoms | CHROMOMYCOSIS PO Adult 200-400mg/day | COCCIDIOIDOMYCOSIS PO Adult 400mg OD/BID | DANDRUFF/SEBORRHOEIC DERMATITIS TP Adult Shampoo (1 or 2%): Apply twice weekly 2-4 wk | FUNGAL INFECT Prophylactic therapy PO Adult 200mg OD 2 wk, may be increased 400mg/day if no response, continue for another 1 wk after resolution of symptoms Child 1-4 yr: 50mg, 5-12 yr: 100mg 2 wk, continue for another 1 wk after resolution of symptoms | HISTOPLASMOSIS PO Adult 400mg OD/BID | OROPHARYNGEAL/ESOPHAGEAL CANDIDIASIS PO Adult 200-400mg/day | PARACOCCIDIOIDOMYCOSIS PO Adult 200-400mg/day | PITYRIASIS VERSICOLOR TP Adult Cream (2%): Apply OD/BID, continued for few days after disappearance of symptoms, shampoo (2%): Apply OD 5 days | Prophylactic therapy TP Adult Shampoo (2%): Apply OD, max 3 days before exposure to sunshine | SEBORRHOEIC DERMATITIS Prophylactic therapy TP Adult Shampoo (2%): Apply once q1-2wk | VAGINAL CANDIDIASIS Chronic PO Adult 400mg OD 5 days

Contra: Hypersensitivity, CNS fungal infect, coadministration with ergot derivatives, cisapride or triazolam

Precautions: Hepatic impairment, porphyria

ADR: Serious: Adrenal cortex suppression, anaphylaxis, angioedema, thrombocytopenia, Others: irritation, dermatitis, burning sensation, gynecomastia, oligospermia, menstrual irregularities, GI disturbances, nausea, vomiting, urticaria, pruritus, rash, alopecia, headache, dizziness, impotence, somnolence, paresthesia, raised ICP, photophobia

DDI: Serious Warfarin anticoagulant effects increased, Rosiglitazone/Pioglitazone AUc increased, Eplerenone bioavailability increases, Tolbutamide blood glucose-lowering effects increased, HIV protease inhibitors both levels increases, Alcohol causes disulfiram-like reactions, Phenytoin/Phenobarbital/Rifampicin decreases drug levels, Omeprazole increases drug bioavailability, Docetaxel increases risk of neutropenia, Domperidone leads to additive QT prolongation, Bortezomib/Benzodiazepines/Budesonide/Carbamazepine/CCBs/Ciclesonide/Ciclosporin/Cilostazol/Disopyramide/Donepezil/Etoricoxib/Galantamine/Hormonal Contraceptives/Phosphodiesterase type-5 inhibitors/Quinidine/Tacrolimus/Valdecoxib levels increased, Methyl Prednisolone metabolism & clearance reduced, Opioids metabolism inhibited, Cyclophosphamide metabolism is inhibited & efficacy reduced, Antacids reduces drug absorption

Diet: With food

Monitor: LFTs


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