Indications & Dose: DYSLIPIDEMIAS PO Adult Initially 20-40mg/day HS, dose can be adjusted at intervals of not less than 4 wk or until 80mg/day is reached MD 5-80mg/day | HETEROZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA PO Adult 40mg/day HS or 80mg/day in 3 divided doses (20mg, 20mg & 40mg HS) Child 10-17 yr (boys & postmenarchal girls): 10mg HS, increase dose at intervals of not less than 4 wk or until 40mg/day is reached | HOMOZYGOUS FAMILIAL HYPERCHOLESTEROLEMIA PO Adult 40mg/day HS or 80mg/day in 3 divided doses (20mg, 20mg & 40mg HS) | PREVENTION CARDIOVASCULAR EVENTS HYPERCHOLESTEROL PO Adult Initially 40mg/day HS dose can be adjusted at intervals of not less than 4 wk or until 80mg/day is reached MD 5-80mg/dayIn patients with atherosclerotic CVD/DM/peripheral arterial disease/history of stroke/other CVD

Precautions: hepatic/renal impairment, elderly, rhabdomyolysis, alcoholics, hyperlipidemia, cyclosporine therapy

ADR: Serious: atrial fibrillation, RTI, myalgia, hypersensitivity, hepatitis, pancreatitis, erectile dysfunction, transaminases & CPK elevations, Others: blurred vision, insomnia, abdominal pain, constipation, gastritis, nausea, vertigo, headache

DDI: Serious Colchicine/Amiodarone causes myopathy & rhabdomyolysis, Delavirdine/Clopidogrel/Diltiazem/Fusidic acid/HIV protease inhibitors/Nicotinic Acid/Sildenafil/Verapamil causes rhabdomyolysis, Itraconazole increases drug level, Macrolides leads to acute rhabdomyolysis, Ciclosporin leads to serious myopathy & renal failure, Phenytoin reduces drug efficacy

Diet: With/without food

Monitor: CPK levels,LFT