Dyslipidemia in diabetes Signs Management Treatment of Diabetic Dyslipidemia

Dyslipidemia in diabetes Signs Management with Drugs for diabetic dyslipidemics

Dyslipidemia in diabetes

  • Hypertriglyceridemia
  • Reduced HDL cholesterol
  • Small dense LDL particles:
  • Highly atherogenic
  • Easily glycated
  •  Susceptible to oxidation.

Dyslipidemia in diabetes

Dyslipidemia in diabetes Signs Management with Drugs for diabetic dyslipidemics


Management of Dyslipidemia in diabetes

  • · Lipids should be aggressively treated
  • · Hyperglycemia should be strictly managed Grave cardiovascular risk in dyslipidemic diabetics

Target lipid values in diabetics  :

  • · LDL < 100 mg/dl
  • · HDL >40 mg/dl – in men
  • · HDL >50 mg/dl – in women
  • · Triglycerides < 150 mg/dl

Treatment of Diabetic Dyslipidemia :

  • · Lower LDL cholesterol
  • · Raise HDL cholesterol
  • · Decrease triglycerides
  • · Dietary changes
  • · Lifestyle modifications

Lifestyle changes in diabetics :

  • · Smoking cessation
  • · Control blood pressure
  • · Weight loss
  • · Exercises
  • · Yoga
  • · Meditation
  • · Remove stress
  • · Diet
  • · Saturated fats and cholesterol in diet has a defi­nite link with CAD
  • · Dietary fat and cholesterol reduce myocardial perfusion by causing changes in platelet aggre­gation and diameter of coronary arteries
  • · Increase in intake of monounsaturated fats
  • · Increase intake of carbohydrates
  • · Increase intake of fiber (whole foods)
  • · Reduce saturated fats
  • · Reduce cholesterol in diet.
  • STRICT DIETARY REGIME CAN LOWER LDL >25 MG/ DL
  • Strict glycemic control i.e. control of blood sugar lev
  • · Will lower triglycerides
  • · Will raise HDL

Drugs for diabetic dyslipidemics :

  • · HMG Co-A reductase inhibitors
  • · Fibric acid derivatives
  • · Nicotinic acid
  • · Bile acid sequestrants
  • Fish oil
  • Cholesterol absorption inhibitors
  • All individuals >40 yrs of age with diabetes and total cholesterol >135 mg/dl may benefit from HMG Co-A reductase inhibitors.
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