Fludarabine

Details About Generic Salt ::  Fludarabine 

Main Medicine Class:: Anti Neoplastic Agents   Sub Medicine Class ::  Anti Neoplastic Agents

18A. ANTI-NEOPLASTIC AGENTS in 18. ANTI-NEOPLASTIC AGENTS
FLUDARABINE
ANTIMETABOLITE (PURINE ANALOG) | ANTI-NEOPLASTIC
PK: D: 38-96 L/m2 (Vd) E: Urine

Indications & Dose: ACUTE LYMPHOCYTIC LEUKEMIA IV Child Relapsed: 10.5mg/m2 bolus over 15min followed by continuous inf 30.5mg/m2/day for 48h | ACUTE MYELOID LEUKEMIA IV Child Relapsed: 10.5mg/m2 bolus over 15min followed by continuous inf 30.5mg/m2/day for 48h | LYMPHOCYTIC LEUKEMIA PO Adult 40mg/m2/day for 5 days, courses may be repeated q28days | IV Adult 25mg/m2/day as inf over 30min for 5 days q28days

Contra: Hypersensitivity, Severe renal impairment, decompensated hemolytic anemia, concurrent use with pentostatin

Precautions: Patients with pre-existing hematological disorders, patients with pre-existing CNS disorder, In Infect

ADR: Serious: Bone-marrow suppression, blood disorders, pancytopenia, tumor lysis syndrome, auto-immune hemolytic anemia, arrhythmias, HF, hemorrhagic cystitis, neurological disturbances, peripheral neuropathy, blindness, seizures, encephalopathy, hematuria, pulmonary toxicity, pulmonary fibrosis, abnormalities in hepatic/pancreatic enzymes, anaphylaxis, Others: GI disturbances, agitation, confusion, hearing loss, visual disturbances, sleep disorders, chills, cough, weakness, malaise, anorexia, mucositis, stomatitis, pneumonitis, dyspnea, skin rashes, dysuria, epistaxis

Diet: With/without food

Monitor: CBC, platelet count, AST, ALT, SeCr, serum albumin, uric acid, signs of infect & neurotoxicity

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