Ivabradine

Details About Generic Salt ::  Ivabradine 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Anti Anginals

4C. ANTI-ANGINALS in 4. CARDIOVASCULAR SYSTEM
IVABRADINE
SELECTIVE SINUS NODE IF INHIBITOR | ANTI-ANGINAL
PK: A: completely absorbed M: Hepatic E: urine & feces

Indications & Dose: ANGINA PECTORIS PO Adult Initially 5mg BID, may be increased to 7.5mg BID after 3 or 4wks, if HR falls <50 beats/min titrate dose to 2.5mg BID Elderly >75 yr: 2.5mg BID

Contra: Cardiogenic shock, severe hypotension, severe hepatic impairment, unstable angina

Precautions: severe renal impairment, history of retinitis pigmentosa, QT prolongers

ADR: Serious: Luminous phenomena, hyperuricemia, bradycardia, arrhythmias, muscle cramps, Others: nausea, constipation, diarrhea, headache, dizziness, dyspnea, elevated blood-creatinine concentrations, eosinophilia, blurred vision

DDI: Serious Rifampicin/Phenytoin decreases drug level, HIV protease inhibitors/Diltiazem/Nefazodone/Verdenafil increases drug level

Diet: With food

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