Mexiletine

Details About Generic Salt ::  Mexiletine 

Main Medicine Class:: Cardiovascular System   Sub Medicine Class ::  Anti Arrhythmics

4B. ANTI-ARRHYTHMICS in 4. CARDIOVASCULAR SYSTEM
MEXILETINE
LIDOCAINE-LIKE AGENT | ANTI-ARRHYTHMIC (CLASS IB)
PK: A: Well absorbed D: 5-7 L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: VENTRICULAR ARRHYTHMIAS PO Adult Loading dose 400mg then 200-250mg TID/QID given 2h after loading dose, MD 600-900mg/day in divided doses, max 1.2g/day | IV Adult Inf: 100-250mg (25mg/min) then 250mg over 1h & 250mg next 2h, MD 500µg/min. When appropriate switch to PO (200-250mg TID/QID)

Contra: Hypersensitivity, cardiogenic shock, second/third-degree AV block

Precautions: Sinus node dysfunction, conduction disorders, bradycardia, hypotension, HF, hepatic impairment

ADR: Serious: Hepatic necrosis, blood disorders, heart block & AV dissociation, atrial fibrillation, SJS, blurred vision, tinnitus, Others: nausea, vomiting, dyspnea, skin rashes, Dizziness, nervousness, confusion, fatigue, sleep disorder, tremor, paresthesia, edema

DDI: Serious Rifampicin increases drug clearance, Theophylline levels are increases and causes toxicity by drug, Fluvoxamine markedly increases the AUC of drug, Ritonavir/Propafenone raises drug levels, Opioids reduces drug absorption & follows MI, Phenytoin reduces drug levels, Sparfloxacin reduces QT prolongation

Diet: With food

Monitor: Cardiac status, CNS changes

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