Moxifloxacin

Details About Generic Salt ::  Moxifloxacin 

Main Medicine Class:: Anti Infectives   Sub Medicine Class ::  Quinolones

3C. ANTI-INFECTIVES in 3. OCULAR
MOXIFLOXACIN
FLUOROQUINOLONE | ANTI-INFECTIVE
also comes under 13G. Quinolones in 13. Anti-Infectives,  
PK: A: Well absorbed D: 1.7 to 2.7 L/kg (Vd) M: Hepatic E: Urine

Indications & Dose: BACTERIAL CONJUNCTIVITIS TP Adult Solution (0.5%): Instill 1 drop into affected eye BID 7 days Child >4 month: Same as adult dose | BACTERIAL EXACERBATION Acute PO/IV Adult 400mg OD 5 days | BACTERIAL SINUSITIS Acute PO/IV Adult 400mg OD 10 days | BRONCHITIS Chronic PO/IV Adult 400mg OD 5 days | COMMUNITY-ACQUIRED PNEUMONIA PO/IV Adult 400mg OD 1-2 wks | INTRA-ABDOMINAL INFECT Complicated PO/IV Adult 400mg OD 5-14 days (initiate with IV) | SKIN/SKIN STRUCTURE INFECT PO/IV Adult Uncomplicated: 400mg/day 1 wk, complicated: 400mg/day 1-3 wks

Contra: Hypersensitivity

Precautions: CVD, DM, myasthenia gravis, seizures, latent/actual G6PD deficiency, RA, hepatic/renal impairment, known/suspected CNS disorder, prolonged QTc interval agents, uncorrected hypokalemia, elderly, take drug 4h before/8h after multiple vitamins & antacids

ADR: Serious: Cardiac arrhythmias, QTc prolongation, tachycardia, vasodilation, blood disorders, decreased serum levels of basophils, eosinophils, hemoglobin, RBC, neutrophils, increase albumin, bilirubin level, arthralgia, myalgia, tremor, Others: abdominal pain, anorexia, constipation, dyspepsia, flatulence, stomatitis, increase amylase, lactic dehydrogenase, glossitis, taste perversion, xerostomia, vomiting, urticaria, anxiety, insomnia, malaise, nervousness, pharyngitis, pneumonia, sinusitis, allergic reaction, diaphoresis, infect

DDI: Serious Amiodarone increases risk of arrhythmia, Quinidine increases risk of Torsade de pointes, Paliperidone prolongs QT interval, Zinc compounds/Cephalosporins reduces drug absorption, Combined hormonal contraceptives/Antacids reduces drug levels

Diet: With/without food

Monitor: WBC, signs of infect

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