Orlistat

Details About Generic Salt ::  Orlistat 

Main Medicine Class:: Endocrine,Steroid Hormones , Metabolic System   Sub Medicine Class ::  Anti Obesity Drugs

8J. ANTI-OBESITY DRUGS in 8. ENDOCRINE/STEROID HORMONES & METABOLIC SYSTEM
ORLISTAT
LIPASE INHIBITOR | ANTI-OBESITY
PK: A: Minimal M: Intestine E: Feces (97%), urine(<2%)

Indications & Dose: OBESITY PO Adult 120mg TID with each main meal containing fat and it includes for weight loss & management, when used in conjunction with a reduced-calorie & low-fat diet

Contra: Hypersensitivity, chronic malabsorption syndrome/cholestasis

Precautions: History of hyperoxaluria/calcium oxalate nephrolithiasis, type II DM

ADR: Serious: HTN, Others: GI disturbances, fecal urgency & incontinence, flatulence, fatty stools/discharge, anxiety, fatigue, menstrual irregularities, increased risk of breast cancer, headache

DDI: Serious Vit E/Amiodarone absorption reduced, Coumarins absorption reduced that leads to increase in INR, ACEIs increases in BP, Hormonal Contraceptives risk of contraceptive failure is increased

Diet:

Monitor: BMI, diet (calorie & fat intake), serum glucose, TFT, LFTs

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