The Brand Name PIPERAZINE CITR Has Generic Salt :: Piperazine
PIPERAZINE CITR Is From Company Gsk Priced :: Rs. 47.17
PIPERAZINE CITR have Piperazine is comes under Sub class Anthelmintics of Main Class Anti Infectives
Main Medicine Class:: Anti Infectives Sub Medicine Class :: Anthelmintics
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Indications for Drugs ::
Drug Dose ::
Ascariasis Adult: As hydrate: 4.5 g as a single dose repeated once after 14 days. Alternatively, may be given as a preparation with senna in a single dose of 4 g of the phosphate, repeat dose mthly for up to 3 mth if needed; same dosage regimen may also be used to prevent ascariasis. Child: As a single dose, repeated once after 14 days. <1 yr: 120 mg>12 yr: same as adult dose. To be taken once daily for 7 days, 2nd course may be repeated after an interval of 7 days. Alternatively, for children >6 yr: May be given as a preparation with senna in a single dose of 4 g of the phosphate; repeat dose after 14 days.
Severe renal impairment, epilepsy. Pregnancy.
Drug Precautions ::
Hepatic impairment, neurological conditions, mild to moderate renal impairment. Lactation.
Drug Side Effects ::
Nausea, vomiting, colic, abdominal pain, diarrhoea, urticaria, skin rashes, headache, bronchospasm, dizziness, nystagmus, ataxia, paraesthesia, myoclonic contractions, choreiform movements, muscular incoordination (worm wobble), confusion, EEG abnormalities, blurred vision. Potentially Fatal: Stevens-Johnson syndrome, bronchospasm and angioedema.
Pregnancy category ::
Drug Mode of Action ::
Piperazine is effective against the intestinal nematodes roundworm (Ascaris lumbricoides), pinworm and threadworm (Enterobius vermicularis). It produces a neuromuscular block resulting in muscle paralysis of the worms which are consequently dislodged and expelled in the faeces.
Drug Interactions ::
Antagonism if pyrantel and piperazine are used together. Piperazine may potentiate extrapyramidal effects of chlorpromazine and other phenothiazines.