Details About Overdose or Poisoning Generic Salt ::  Cyproheptadine



Drug Pharmacology ::

I. Pharmacology. Cyproheptadineis a first-generation, histamine-1 blocker with nonspecific serotonin(5-HT) antagonism. The administration of cyproheptadine to patientswith serotonin syndrome appears to antagonize excessive stimulation of5-HT1A and 5-HT2 receptors, resulting in improvements in clinicalsymptoms (based on anecdotal case reports).

Drug Indications ::

Indications. Cyproheptadine may be beneficial in alleviating mild to moderate symptoms in cases of suspected serotonin syndrome (see Serotonin syndrome).

Drug Contra-Indications ::

III. Contraindications./b>


Known hypersensitivity to cyproheptadine.

Angle-closure glaucoma.

Stenosing peptic ulcer.

Symptomatic prostatic hypertrophy.

E. Bladder neck obstruction.

F. Pyloroduodenal obstruction.

Drug Adverse Effects ::

IV. Adverse effects


Transient mydriasis and urinary retention may result from anticholinergic properties.

Use in pregnancy. FDA category B (see Table III–1). Unlikely to cause harm with short-term therapy.

Drug Lab Interactions ::

Drug or laboratory interactions. Additive anticholinergic effects when given with other antimuscarinic drugs.

Drug Dose Management ::

Dosage and method of administration (adults and children)


Oral. Theinitial dose is 4–8 mg orally and can be repeated every 1–4 hours asneeded until symptoms resolve or a maximum daily dose of 32 mg isreached (children: 0.25 mg/kg/day divided every 6 hours with a maximumof 12 mg/day).

Drug Chemical Formulations ::



Oral. Cyproheptadine hydrochloride (Periactin, others), 4-mg tablets, 2 mg/5 mL syrup.

The suggested minimum stocking level to treat a 70-kg adult for the first 24 hours is one bottle (4 mg, 100 tablets).

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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