Renin and Hypertension Low renin and High Renin essential hypertension with Treatment

Renin and HypertensionHyperthyroidism or THYROTOXICOSIS Causes, Symptoms and Diagnosis. Read more ... » Low renin and High Renin essential hypertensionHypertension Definition Classification. Read more ... »

• Renin is enzyme secreted by juxtaglomerular cells of the kidneyDiabetic Nephropathy and Renal complications of DM (Diabetes Mellitus). Read more ... ».
• Hypertensives can be low renin essential
• Hypertensives and high renin essential hypertensives.

Low renin essential hypertension :

• 20% of pa­tients of essential hypertension have low renin es­sential hypertension.
• When patients with low renin essential hypertension take sodium-rich diet,
• their aldosteroneLABORATORY TESTS FOR ADRENAL FUNCTIONS. Read more ... » suppression does not occur, lead­ing to hyperaldosteronism causing more sodium re­tention, volume expansion and high BPHyperthyroidism or THYROTOXICOSIS Causes, Symptoms and Diagnosis. Read more ... ».
• There is increased ‘mineralocor­ticoid production, leading to increased sodium reten­tion, which in turn causesFatigue diagnosis medicine and treatment. Read more ... » renin suppression.
• The ad­renalDiabetic Nephropathy and Renal complications of DM (Diabetes Mellitus). Read more ... » cortex of low renin hypertensives have increased sensitivity to angiotensin II.

hypertension and renin

Non - modulating essential hypertension :

• The adrenalHypothalamic, Pituitary And Other Sellar Masses. Read more ... » or renal vascular responses to angiotensin II is not modulated by sodium intake.
• The effect of an­giotensin II does not depend on sodium intake in these patients.
• so salt intake should be low. -
• There is insulinDiabetic Ketoacidosis (DKA) Acute Complications Of Diabetes Mellitus. Read more ... » resistance.
• Non-modulation is a genetic problem.
• 30% of hypertensives are non-modulating essential hypertensives.
• Plasma renin activity levels are normal to high.
• - Kidneys are unable to excrete sodium appropriately

TreatmentFatigue diagnosis medicine and treatment. Read more ... » -

• ACE inhibitorsHeart Failure Treatment Heart Failure GENERAL PRINCIPLES. Read more ... » and salt restriction.
• High Renin Essential Hypertension (HREH)  15% of hypertensives have HREH.
• There is increased adrenergic systemFatigue diagnosis medicine and treatment. Read more ... » activity.
• Angiotensin receptor blockersHeart Failure Treatment Heart Failure GENERAL PRINCIPLES. Read more ... » may or may not be effective.

Salt intake:

• Higher the salt intake more the BP es­pecially in primary aldosteronism, bilateral renal ar­tery stenosis, renal parenchymal diseaseFatigue diagnosis medicine and treatment. Read more ... », low renin essential hypertension.
• Salt includes chiefly – Sodium Chloride Calcium -

Sodium, Chloride and Calcium

• NaCI increases blood pressureChronic Long-term Complications Of Diabetes Mellitus. Read more ... ».
• Na without chloride does not increase blood pres­sure.
• Intracellular calcium can lead to hypertension .
• Calcium _entry blokers are very potent Fntihypertensives.
• Low calcium intake also results in hypertension.

Cell membrane defect:

• Abnormalities of sodium transport occur.
• There is abnormal accumulation of calcium in vascular smooth muscle leading to vaso­constriction and hypertension.
• This defect is present in of hypertensives.

Insulin resistance :

• is related to hypertension. In­sulin resistance is common in obesityHyperthyroidism or THYROTOXICOSIS Causes, Symptoms and Diagnosis. Read more ... » and NIDDM.
• Obesity and NIDDM are common in hypertensives. These together form the metabolic syndromeMetabolic,Insulin Resistance Syndrome X Causes Symptoms. Read more ... » also called syndromeMetabolic,Insulin Resistance Syndrome X Causes Symptoms. Read more ... » X.