Details About Generic Salt ::  Acetylcy

Main Medicine Class:: Respiratory inhalant,mucolytic   

(ASS-cee-till-SIS-teen)

Acetylcysteine, Mucomyst, Mucomyst-10, Mucosil-10, Mucosil-20,  Mucomyst, N-acetylcysteine, Parvolex

Class: Respiratory inhalant/mucolytic

 

Drugs Class ::

 Action Decreases thickness of mucous secretions in lung.

Indications for Drugs ::

 Indications Reduction of viscosity of bronchopulmonary mucous secretions in patients with chronic or acute lung diseases, pulmonary complications associated with cystic fibrosis, surgery, anesthesia, atelectasis caused by mucous obstruction; diagnostic bronchial studies; prevention or lessening of liver damage after potentially toxic quantity of acetaminophen.

Orphan drug status: IV form for acetaminophen overdose. Unlabeled use(s): Ophthalmic preparation for dry eyes; enema for bowel obstruction.

Drug Dose ::

 Route/Dosage

ADULTS: Nebulization (face mask, mouthpiece, tracheostomy) 1 to 10 ml (usually 2 to 5 ml) of 20% solution or 2 to 20 ml (usually 6 to 10 ml) of 10% solution q 2 to 6 hr (usually tid or qid); (nebulization tent) large volumes (up to 300 ml) during treatment period. Instillation 1 to 2 ml of 10 to 20% solution as often as every hour. DIAGNOSTIC BRONCHOGRAMS: 2 to 3 administrations of 1 to 2 ml of 20% solution or 2 to 4 ml of 10% solution q 1 to 4 hr by instillation before procedure. ACETAMINOPHEN OVERDOSE: After appropriate overdose procedures (eg, lavage, induction of emesis), 140 mg/kg as oral loading dose (diluted with soft drink). Then 70 mg/kg orally 4 hr after loading dose and repeated at 4 hr intervals for total of 17 doses, unless acetaminophen assay indicates otherwise.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Undetermined. Bronchial secretions: Increased secretion volume may occur. When cough is inadequate, open airway may need to be maintained by mechanical suction. Asthmatic bronchospasm: If bronchospasm progresses, medication must be discontinued immediately. Antidotal use: If allergic reaction, encephalopathy or severe, persistent vomiting occurs, discontinuation of drug may be necessary.

PATIENT CARE CONSIDERATIONS

Drug Side Effects ::

 Adverse Reactions

CV: Tachycardia; hypotension; hypertension; chest tightness. RESP: Bronchospasm; bronchial irritation. CNS: Drowsiness. EENT: Rhinorrhea. GI: Nausea; vomiting; stomatitis. DERM: Rash; pruritis; angioedema. OTHER: Fever; clamminess.

Drug Mode of Action ::  

 Action Decreases thickness of mucous secretions in lung.

Drug Interactions ::

 Interactions None well documented. INCOMPATIBILITIES: Do not mix with tetracycline, chlortetracycline, oxytetracycline, erythromycin lactobionate, amphotericin B, ampicillin sodium, iodized oil, chymotrypsin, trypsin, or hydrogen peroxide.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Assess airway patency, baseline lung sounds and effectiveness of cough.
• Assess for urticaria, rashes, hemoptysis, or stomatitis.
• Review baseline liver enzyme levels and monitor throughout therapy.
• If rapid onset of bronchospasm occurs, discontinue medication immediately and notify physician.
• If patient vomits loading dose or maintenance dose within 1 hr of administration, repeat dose.
• If patient’s cough is inadequate, maintain open airway by endotracheal aspiration.
• Notify physician of the following signs/symptoms: Chest tightness, tachycardia, or severe and persistent vomiting.

Drug Storage/Management ::

 Administration/Storage

Mucolytic

• Use Sodium Chloride for Injection or Inhalation or Sterile Water for Injection or Inhalation to prepare 20% solution.
• Do not dilute 10% solution unless instructed by physician.
• Do not use nebulization equipment that contains iron, copper or rubber because of potential for corrosion. Use glass, plastic, aluminum, anodized aluminum, chromed metal, or stainless steel equipment.
• Refrigerate unused or undiluted solution and use within 96 hr.

Acetaminophen Overdosage

• Administer orally immediately if £ 24 hr after ingestion of acetaminophen.
• Dilute 20% solution 1:3 with soft drink or juice to mask odor.
• Cover glass with aluminum foil and push straw through cover to help patient ingest without smelling medication and vomiting.
• Use fresh dilution within 1 hr.
• Undiluted opened vials will last for 96 hr under refrigeration.

Drug Notes ::

 Patient/Family Education

• Explain that medication has disagreeable odor.
• Advise patient of likelihood for significant increase in respiratory secretions and need to cough.
• Caution patient to notify physician of rash, urticaria, wheezing, chest tightness, severe vomiting, hemoptysis, fever or severe malaise.
• Provide follow-up counseling as needed for acetaminophen overdose.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.