Details About Generic Salt ::  Alendron

Main Medicine Class:: Hormone,Bisphosphonates   

(al-LEN-droe-nate SO-dee-uhm)
Fosamax
Class: Hormone/Bisphosphonates

 

Drugs Class ::

 Action Inhibits bone resorption and increases bone density.

Indications for Drugs ::

 Indications Treatment of osteoporosis in postmenopausal women; prevention of osteoporosis in postmenopausal women at risk of developing osteoporosis; treatment of osteoporosis in men; treatment of glucocorticoid-induced osteoporosis in men and women; treatment of t disease of the bone.

Drug Dose ::

 Route/Dosage

Osteoporosis (Postmenopausal Women)

ADULTS: PO Treatment: 70 mg once weekly or 10 mg once daily. Prevention: 35 mg once weekly or 5 mg once daily.

Osteoporosis (Men)

ADULTS: PO 10 mg once daily.

Glucocorticoid-Induced Osteoporosis

ADULTS PO 5 mg once daily. For postmenopausal women not receiving estrogen, 10 mg once daily.

t Disease

ADULTS: PO 40 mg once daily for 6 mo. Retreatment may be considered for patients who relapse after a 6-mo observation period.

Contraindication ::

 Contraindications Hypocalcemia.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Undetermined. Children: Safety and efficacy not established. Renal: Not recommended for patients with CrCl < 35 mL/min. GI Disorders: Not recommended for patients with upper GI problems. Hypocalcemia: Correct before starting alendronate. Nutrition: Maintain adequate calcium and vitamin D intake during alendronate therapy. Concomitant estrogen replacement therapy: Not recommended. Absorption: Food, beverages other than water, and medication inhibit absorption. Must be taken first thing in the morning with a full glass of water ³ 30 min before any food, beverages, or medications. Must remain sitting or standing for 30 min after taking.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CNS: Headache. GI: Abdominal pain; constipation; diarrhea; flatulence; esophageal ulcer; dysphagia. OTHER: Musculoskeletal pain.

Drug Mode of Action ::  

 Action Inhibits bone resorption and increases bone density.

Drug Interactions ::

 Interactions

Food: Absorption of alendronate is decreased by food. Liquids: Beverages other than water decrease absorption. Ranitidine: Increased alendronate absorption; clinical importance unknown. Calcium supplements, antacids: Decreased alendronate absorption. Aspirin: Risk of upper GI adverse effects is increased by concomitant use of aspirin and alendronate doses over 10 mg/day.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history.
  • Assess for hypersensitivity reaction.
  • Assess for severe renal insufficiency prior to administration.
OVERDOSAGE: SIGNS & SYMPTOMS
  Hypocalcemia, hypophosphatemia, upper GI adverse effects

Drug Storage/Management ::

 Administration/Storage

  • Divide dose if GI upset occurs.
  • Avoid high calcium food, vitamins with mineral supplements, and antacids high in metals within 2 hr of dosing.
  • Take 30 min before first meal, medication, or drink of the day. Take with 6 to 8 oz of plain water only.
  • Store at room temperature in well-closed container.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to take medication with plain water 30 min before the first food or drink of the day.
  • Take medication with a full glass of water. Patient should not lie down for 30 min following administration.
  • Instruct patient not to suck or chew on tablet; swallow whole.
  • Have patient take supplemental calcium (1500 mg) and vitamin D (400 IU PO daily) if dietary intake is not adequate.
  • Encourage patient to perform weight-bearing exercises and modify behaviors that promote osteoporosis (ie, avoid alcohol and cigarette smoking).
  • Have patient read package insert before starting therapy.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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