Details About Generic Salt ::  Amphetam

Main Medicine Class:: CNS stimulant,amphetamine   

(am-FET-uh-meen)

Class: CNS stimulant/amphetamine

Drugs Class ::

 Action Activates noradrenergic neurons, causing CNS and respiratory stimulation; stimulates satiety center in brain, causing appetite suppression.

Indications for Drugs ::

 Indications Narcolepsy; attention deficit disorder with hyperactivity; short-term (ie, few weeks) exogenous obesity adjunct used only when alternative therapy has been ineffective.

Drug Dose ::

 Route/Dosage

Narcolepsy

ADULTS & CHILDREN > 12 YR: PO 10 mg/day; may be increased weekly by 10 mg to max of 60 mg/day in divided doses. CHILDREN 6 TO 12 YR: PO 5 mg/day; may be increased weekly by 5 mg to max of 60 mg/day in divided doses.

Attention Deficit Disorder

CHILDREN ³ 6 YR: PO 5 mg/day; may be increased weekly by 5 mg to max of 40 mg/day in divided doses. Usual range: 0.1 to 0.5 mg/kg/dose q AM. CHILDREN 3 TO 5 YR: PO 2.5 mg/day; may be increased weekly by 2.5 mg. Usual range: 0.1 to 0.5 mg/kg/dose in morning.

Exogenous Obesity

ADULTS & CHILDREN > 12 YR: PO 5 to 10 mg 30 to 60 min before meals, up to 30 mg/day.

Contraindication ::

 Contraindications Advanced arteriosclerosis; symptomatic cardiovascular disease; moderate to severe hypertension; hyperthyroidism; hypersensitivity to sympathomimetic amines; glaucoma; agitated states; history of drug abuse. Do not use concomitantly with or within 14 days of MAO inhibitor use.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Should not be used as anorectic agent in children < 12 yr. Not recommended for attention deficit disorder in children < 3 yr. Drug dependence: Has high potential for dependence and abuse. Tolerance: May occur; do not exceed recommended dose.

Drug Side Effects ::

 Adverse Reactions

CV: Palpitations; tachycardia; hypertension; arrhythmias. CNS: Hyperactivity; dizziness; restlessness; tremors; insomnia; euphoria; headache. DERM: Urticaria. EENT: Dry mouth; unpleasant taste. GI: Diarrhea; constipation; anorexia. GU: Impotence.

Drug Mode of Action ::  

 Action Activates noradrenergic neurons, causing CNS and respiratory stimulation; stimulates satiety center in brain, causing appetite suppression.

Drug Interactions ::

 Interactions

Guanethidine: Effectiveness may be decreased. MAO inhibitors, furazolidone: May cause hypertensive crisis and intracranial hemorrhage. Tricyclic antidepressants: May decrease amphetamine effect. Urinary acidifiers (ammonium chloride, ascorbic acid): May decrease amphetamine effect. Urinary alkalinizers (acetazolamide, sodium bicarbonate): May increase amphetamine effect.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any allergies (particularly aspirin). Note cardiovascular disease, hypertension, history of drug abuse.
• Obtain BP initially and monitor periodically during therapy.
• Ensure that serum thyroxine (T₄), plasma corticosteroid and urinary steroid levels have been obtained before beginning therapy.
• Review ECG for arrhythmias before beginning therapy.
• Assess mental status. Depressed patients are more likely to misuse drug to induce euphoria and mood elevation.
• Implement safety precautions to prevent falls.
• If hypertensive crisis occurs, administer phentolamine.
• Monitor patient drug use pattern closely. Physical and psychologic dependency can occur quickly with these agents.
• Observe for the following early signs of overdosage: Restlessness, irritability, fever, hyperpnea, confusion.
• Closely monitor growth rate of children during therapy. Effect of drug on growth rate is unknown.
• Observe for dizziness and dry mucous membranes.

Drug Storage/Management ::

 Administration/Storage

• Administer drug as supplied; do not crush or have patient chew sustained-release or long-acting tablets.
• Administer in AM or at least 6 hr before bedtime to avoid insomnia.
• Store at room temperature.

Drug Notes ::

 Patient/Family Education

• Caution patient to take medication exactly as ordered and not to increase dosage unless advised by physician.
• Advise patient to avoid caffeine, which increases drug effect.
• Instruct patient to report the following symptoms to physician: Insomnia, skin discolorations, GI disturbances.
• Instruct patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
• Advise patient that drug may cause drowsiness, and to use caution while driving or performing tasks requiring mental alertness.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.