Details About Generic Salt ::  Atenolo1

Main Medicine Class:: Antihypertensive   

(ah-TEN-oh-lahl/klor-THAL-ih-dohn)

Tenoretic-50, Tenoretic-100

Class: Antihypertensive

Drugs Class ::

 Action Atenolol is beta-adrenergic blocking agent that slows heart rate, reduces cardiac output and lowers BP. Chlorthalidone is diuretic agent that reduces body water by increasing urine output.

Indications for Drugs ::

 Indications Treatment of hypertension.

Drug Dose ::

 Route/Dosage

ADULTS: PO 50 mg atenolol/25 mg chlorthalidone or 100 mg atenolol/25 mg chlorthalidone once daily.

Contraindication ::

 Contraindications Hypersensitivity to sulfonamide-derived drugs, sinus bradycardia, heart block greater than first degree, cardiogenic shock, overt cardiac failure, anuria. Not for initial therapy of hypertension.

Drug Precautions ::

 Precautions

Pregnancy: Category D. Lactation: Atenolol is excreted in breast milk and may produce clinically significant effects in infants. Children: Safety and efficacy not established. Anaphylaxis: Deaths have occurred with anaphylactic reactions to beta-blockers; aggressive therapy may be required. Cardiac failure: Use with caution in patients with history of heart failure. Diabetes mellitus: May mask symptoms of hypoglycemia (eg, tachycardia, BP changes). May potentiate insulin-induced hypoglycemia. Elderly: Dose may need to be reduced. Hypertension: Fixed-dose combinations of drugs are not intended for initial therapy of hypertension but are used for convenience once patient has been stabilized. Nonallergic bronchospastic diseases (eg, chronic bronchitis, emphysema): In general, do not give beta-blockers to patients with bronchospastic diseases. Peripheral vascular disease: May precipitate or aggravate symptoms of arterial insufficiency. Renal and hepatic impairment: Use with caution in patients with renal or hepatic disease; dose may need to be reduced. Thyrotoxicosis: May mask clinical signs (eg, tachycardia), of developing or continuing hyperthyroidism. Abrupt withdrawal may exacerbate symptoms of hyperthyroidism, including thyroid storm.

Drug Side Effects ::

 Adverse Reactions

CV: Bradycardia; orthostatic hypotension; cold extremities; leg pain; CHF; slow atrioventricular (AV) conduction; intensification of AV block. CNS: Fatigue; dizziness; vertigo; light-headedness; lethargy; drowsiness; depression; dreaming. DERM: Rash. GI: Diarrhea; nausea. GU: Peyronie’s disease; impotence; diminished libido. HEMA: Thrombocytopenia; agranulocytosis. HEPA: Elevated liver enzymes; jaundice; pancreatitis. META: Hyperuricemia; hyponatremia; hypochloremic alkalosis; hypokalemia. RESP: Bronchospasm; wheezing; dyspnea. OTHER: Development of lupus syndrome with antinuclear antibodies.

Drug Mode of Action ::  

 Action Atenolol is beta-adrenergic blocking agent that slows heart rate, reduces cardiac output and lowers BP. Chlorthalidone is diuretic agent that reduces body water by increasing urine output.

Drug Interactions ::

 Interactions

Clonidine: Beta blockers may exacerbate rebound hypertension associated with clonidine withdrawal. Atenolol/chlorthalidone should be tapered and withdrawn several days before gradual withdrawal of clonidine. Digitalis glycosides: Diuretic-induced hypokalemia may potentiate digitalis toxicity. Lithium: May increase therapeutic and toxic effects of lithium; avoid concomitant use. Nondepolarizing muscle relaxants: May increase effects of these agents. Norepinephrine: May decrease arterial responsiveness to norepinephrine. Other antihypertensive agents: May increase antihypertensive effects. Sulfonylureas: May decrease hypoglycemic effects.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies. Note asthma, diabetes and respiratory, liver or cardiac disease.
• Ensure that baseline creatinine clearance levels have been obtained in patients with impaired renal function and monitor periodically during therapy, along with serum electrolytes.
• Assess BP and apical pulse before administering. If systolic BP is < 90 mm Hg or pulse is < 60 bpm, withhold drug and notify physician.
• Monitor I&O and daily weight during therapy for signs of fluid retention.
• Monitor for fluid overload (eg, jugular venous distension, dyspnea, rales, peripheral edema). Notify physician if these signs occur.
• Withhold medication and notify physician if the following symptoms occur: Hypotension, bradycardia or dyspnea, difficulty breathing on exertion or lying down, night cough, edema of hands and feet.

Drug Storage/Management ::

 Administration/Storage

• Give in morning with food or milk.
• If patient has difficulty swallowing, tablet may be crushed and mixed with fluid.
• Store at room temperature in tightly closed, light-resistant container.

Drug Notes ::

 Patient/Family Education

• Explain that dosage will be tapered slowly before stopping. Warn that sudden discontinuation may cause adverse effects (eg, exacerbation of angina, precipitation of MI).
• Teach patient proper technique for taking pulse and BP, and instruct to check before taking medication.
• Advise patient not to take medication in evening to avoid prolonged diuretic effects.
• Instruct diabetic patient to monitor blood glucose level carefully.
• Counsel patient that impotence or decrease in libido are common side effects, and advise patient to contact physician if either symptom occurs.
• Caution patient to avoid sudden position changes to prevent orthostatic hypotension.
• Advise patient that drug may cause drowsiness, and to use caution while driving or performing other tasks requiring mental alertness until individual effects can be determined.
• Instruct patient not to take otc medications without consulting physician.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.