Details About Generic Salt ::  Auranofi

Main Medicine Class:: Analgesic,antirheumatic agent,gold compound   

(or-RAIN-oh-fin)
Ridaura
Class: Analgesic/antirheumatic agent/gold compound

 

Drugs Class ::

 Action Gold compounds relieve symptoms of arthritis but do not cure this disease; decrease rheumatoid factor concentrations and immunoglobulins.

Indications for Drugs ::

 Indications Relief of symptoms of active adult rheumatoid arthritis poorly controlled with other therapies. Unlabeled use(s): Treatment of pemphigus and psoriatic arthritis.

Drug Dose ::

 Route/Dosage

ADULTS: PO 6 mg/day or 3 mg bid. If no response by 6 mo, dose may be increased to 3 mg tid. Parenteral route may be used when control cannot be achieved by oral form. CHILDREN: Auranofin is not recommended for children; safety and efficacy have not been established. If prescribed, however, the following doses have been recommended: Initial—0.1 mg/kg/day; Maintenance—0.15 mg/kg/day; Max—0.2 mg/kg/day.

Contraindication ::

 Contraindications Standard considerations.

Drug Precautions ::

 Precautions

Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Elderly: Tolerance decreases with age. Special-risk patients: Use with caution in patients with diabetes mellitus, CHF, history of blood dyscrasias, allergy or hypersensitivity to other gold products, skin rash, previous kidney or liver disease, marked hypertension, compromised circulation or inflammatory bowel disease.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions Reactions can occur months after therapy is discontinued.

CNS: Confusion; hallucinations; seizures. DERM: Dermatitis; pruritus; grey-blue pigmentation on sun-exposed skin; exfoliative dermatitis; angioedema. EENT: Mucositis that may be preceded by metallic taste; conjunctivitis; corneal gold deposition; metallic taste; inflammation of the upper respiratory tract; pharyngitis. GI: Diarrhea; abdominal pain; anorexia; dyspepsia; flatulence; GI bleeding; enterocolitis; gastritis; colitis; tracheitis. GU: Nephrotic syndrome and glomerulitis with proteinuria and hematuria. HEMA: Anemia; thrombocytopenia; leukopenia; aplastic anemia. HEPA: Elevated liver enzymes; jaundice; hepatitis. RESP: Interstitial pneumonitis; pulmonary fibrosis. OTHER: Vaginitis; glossitis.

Drug Mode of Action ::  

 Action Gold compounds relieve symptoms of arthritis but do not cure this disease; decrease rheumatoid factor concentrations and immunoglobulins.

Drug Interactions ::

 Interactions None well documented.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies.
  • Observe patient for early symptoms of toxicity such as a metallic taste in the mouth, pruritus or rash.
  • Review laboratory values for indications of gold toxicity such as decreased hemoglobin, < 4000 WBC/mm 3, platelets < 100,000 to 150,000/cu mm, proteinuria, and elevated liver enzymes.
  • If given parenterally, stay with patient for 15 min after injection and monitor for the following signs of adverse reaction: Anaphylactic shock; syncope; bradycardia; thickening of tongue; dysphagia; dyspnea; and angioneurotic edema. Notify physician of any problems.
  • Observe for diarrhea and loose stools, a common adverse reaction that usually can be managed by a reduction in dosage.
OVERDOSAGE: SIGNS & SYMPTOMS
  Renal damage (eg, hematuria, proteinuria), hematologic reactions (eg, thrombocytopenia), nausea, vomiting, diarrhea, fever, skin disorders

Drug Storage/Management ::

 Administration/Storage

  • Administer with food or fluid.
  • Protect product from light and moisture.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to immediately report any adverse effects of therapy including dermatitis and pruritus, weakness, fatigue, hematuria, sore mouth, indigestion, diarrhea, metallic taste in mouth, or unusual bruising.
  • Caution patient to minimize exposure to the sun and other sources of ultraviolet light. Explain the need to wear sunscreen and protective clothing outdoors.
  • Advise patient to keep appointments with health care providers for continued assessment and monitoring of renal, hepatic and hematologic functions.
  • Review oral hygiene, including use of soft toothbrush, daily flossing and avoidance of strong, commercial mouthwashes. If mild stomatitis develops, an isotonic NaC1 and sodium bicarbonate solution can be used.
  • Alert female patients to the potential risks of using gold therapy during pregnancy.

Disclaimer ::

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