Details About Generic Salt ::  Ceftazid

Main Medicine Class:: Antibiotic,cephalosporin   

(seff-TAZE-ih-deem)
Ceptaz, Fortaz, Tazicef, Tazidime
Class: Antibiotic/cephalosporin

 

Drugs Class ::

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Indications for Drugs ::

 Indications Treatment of infections of lower respiratory tract, skin and skin structures, urinary tract, bone and joint; treatment of gynecological infections; treatment of intra-abdominal infections; treatment of septicemia and CNS infections including meningitis due to susceptible strains of specific microorganisms; concomitant antibiotic therapy.

Drug Dose ::

 Route/Dosage

ADULTS: IV/IM 250 mg-2 g q 8–12 hr. CHILDREN 1 MO-12 YR: IV 30–50 mg/kg q 8 hr (maximum:6 g/day). NEONATES < 4 WK: IV 30 mg/kg q 12 hr.

Contraindication ::

 Contraindications Hypersensitivity to cephalosporins.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: Excreted in breast milk. Hypersensitivity: Reactions range from mild to life-threatening. Administer drug with caution to penicillin-sensitive patients due to possible cross-reactivity. Pseudomembranous colitis: Should be considered in patients in whom diarrhea develops. Renal impairment: Use drug with caution in patients with renal impairment. Dosage adjustment based on renal function may be required. Superinfection: May result in bacterial or fungal overgrowth of nonsusceptible microorganisms.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

GI: Nausea; vomiting; diarrhea; anorexia; abdominal pain or cramps; flatulence; colitis, including pseudomembranous colitis. GU: Pyuria; renal dysfunction; dysuria; reversible interstitial nephritis; hematuria; toxic nephropathy. HEMA: Eosinophilia; neutropenia; lymphocytosis; leukocytosis; thrombocytopenia; thrombocytosis; decreased platelet function; anemia; aplastic anemia; hemorrhage. HEPA: Hepatic dysfunction; cholestatic jaundice; abnormal liver function test results. OTHER: Hypersensitivity, including Stevens-Johnson syndrome, erythema multiforme, toxic epidermal necrolysis; candidal overgrowth; serum sickness-like reactions (eg, skin rashes, polyarthritis, arthralgia, fever); phlebitis; thrombophlebitis and pain at injection site.

Drug Mode of Action ::  

 Action Inhibits mucopeptide synthesis in bacterial cell wall.

Drug Interactions ::

 Interactions

Aminoglycosides: Increased risk of nephrotoxicity. INCOMPATIBILITIES: Aminoglycosides: Do not add aminoglycosides to ceftazidime solutions because inactivation of both drugs may result; administer at separate sites if con current therapy is indicated. Sodium bicarbonate: Do not dilute ceftazidime with sodium bicarbonate.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note renal impairment and allergy to cephalosporins or penicillins.
  • Obtain specimens for culture and sensitivity before beginning therapy and periodically during treatment.
  • Monitor renal function carefully during treatment.
  • Monitor for signs of infection, especially fever, and for positive response to antibiotic therapy.
  • Assess for signs and symptoms of anaphylaxis (shortness of breath, wheezing, laryngeal spasm). Have resuscitation equipment available.
  • Assess for signs of superinfection, such as vaginitis or stomatitis.
  • Assess for diarrhea with blood or pus, which may be symptom of pseudomembranous colitis. Symptoms may occur after antibiotic treatment.
  • Monitor IV site for infiltration, infection, thrombophlebitis and bleeding.
OVERDOSAGE: SIGNS & SYMPTOMS
  Neuromuscular excitability, asterixis, seizures, encephalopathy

Drug Storage/Management ::

 Administration/Storage

  • Administer by parenteral route (IV or IM) only.
  • Follow manufacturer’s instructions for reconstitution and dilution.
  • Reconstituted solution should be light yellow to amber; darkened solution or powder does not indicate altered potency. Do not administer if solution is cloudy or precipitate is present.
  • When giving by IM route, add 3 ml diluent to 1-g vial to yield 280 mg/ml. Inject deeply into large muscle (eg, upper outer quadrant of gluteus muscle or lateral thigh); massage well.
  • When giving by IV route, add 10 ml Sterile Water for Injection to 1-g vial to yield 280 mg/ml. Administer slowly over 3–5 min. Change IV sites q 48–72 hr.
  • For intermittent infusions, reconstituted solution can be further diluted with 50–100 ml of D5W or 0.9% sodium chloride and infused over 30 min.
  • Store sterile powder at room temperature and protect from light.
  • When reconstituted with Sterile Water for Injection, solution is stable for 7 days if refrigerated and for 18–24 hr when stored at room temperature. If frozen immediately after reconstitution, solution is stable for 3 mo. Completely thaw frozen preparation at room temperature before use. After thawing, solution may be stored for 18–24 hr at room temperature or 4 days in refrigerator. Do not refreeze.

Drug Notes ::

 Patient/Family Education

  • Remind patient to check body temperature daily. If fever persists for more than a few days or if high fever (> 102°F) or shaking chills are noted, physician should be notified immediately.
  • Advise patient to maintain normal fluid intake while using this medication.
  • Remind diabetic patient to use enzyme-based tests (eg, Clinistix, Testape) for monitoring urine glucose because drug may give false results with other tests.
  • Advise patient to report these symptoms to physician: nausea, vomiting, diarrhea, skin rash, hives, sore throat, bruising, bleeding, muscle or joint pain.
  • Instruct patient to report signs of superinfection: black “furry” tongue, white patches in mouth, foul-smelling stools, vaginal itching or discharge.
  • Warn patient that diarrhea that contains blood or pus may be a sign of serious disorders. Tell patient to seek medical care and not to treat at home.
  • Instruct patient to seek emergency care immediately if wheezing or difficulty breathing occurs.
  • Advise patient not to drink alcoholic beverages or to take alcohol-containing medications while taking this medication and for several days after discontinuing it.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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