Details About Generic Salt ::  Cerivast

Main Medicine Class:: Antihyperlipidemic,HMG-CoA reductase inhibitor   

(seh-RIHV-ah-stat-in)
Baycol
Class: Antihyperlipidemic/HMG-CoA reductase inhibitor

 

Drugs Class ::

 Action Increases rate at which body removes cholesterol from blood and reduces production of cholesterol in body by inhibiting enzyme that catalyzes early rate-limiting step in cholesterol synthesis.

Indications for Drugs ::

 Indications Adjunct to diet for the reduction of elevated cholesterol and low-density lipoprotein (LDL) cholesterol levels in patients with primary hypercholesterolemia (types IIa and IIb).

Drug Dose ::

 Route/Dosage

ADULTS: PO 0.3 mg in the evening.

Renal impairment (CcrCl £ 60 ml/min): PO 0.2 mg in the evening.

Contraindication ::

 Contraindications Active liver disease or unexplained persistent elevations of liver function tests; pregnancy; lactation; concurrent gemfibrozil treatment because of risk of rhabdomyolysis.

Drug Precautions ::

 Precautions

Pregnancy: Category X. Lactation: Excreted in breast milk. Children: Safety and efficacy not established. Liver dysfunction: Use with caution in patients who consume substantial quantities of alcohol or those with a history of liver disease. Marked, persistent increases in serum transaminases have occurred. Renal function impairment: Use with caution. Lower doses indicated if CrCl £ 60 ml/min. Skeletal muscle effects: Rhabdomyolysis with renal dysfunction secondary to myoglobinuria has occurred.

PATIENT CARE CONSIDERATIONS


Drug Side Effects ::

 Adverse Reactions

CNS: Insomnia. GI: Diarrhea; dyspepsia. RESP: Rhinitis; cough; influenza; sinusitis. OTHER: Arthralgia; myalgia; myopathy; rhabdomyolysis; asthenia; edema.

Drug Mode of Action ::  

 Action Increases rate at which body removes cholesterol from blood and reduces production of cholesterol in body by inhibiting enzyme that catalyzes early rate-limiting step in cholesterol synthesis.

Drug Interactions ::

 Interactions

Bile acid sequestrants (eg, cholestyramine): Large decrease in cerivastatin bioavailability. Cyclosporine, gemfibrozil, grapefruit juice, erythromycin, azole antifungals, niacin, verapamil: Increased cerivastatin serum levels; increased risk of myopathy.

Drug Assesment ::

 Assessment/Interventions

  • Obtain patient history, including drug history and any known allergies. Note history of liver disease, excessive alcohol ingestion, and renal function. Assess dietary history.
  • Ensure that total cholesterol, HDL, and LDL levels have been obtained before beginning therapy and reassess periodically during therapy.
  • Assess for the following side effects: nausea, diarrhea, dyspepsia, headache, muscle pain, or weakness.

Drug Storage/Management ::

 Administration/Storage

  • Administer in the evening for best results. Hepatic cholesterol production is highest during the night.
  • May be administered without regard to meals.
  • If patient is also taking a bile-acid sequestrant, administer cerivastatin ³ 2 hr after the sequestrant.
  • Store at room temperature in tightly closed container, protected from moisture.

Drug Notes ::

 Patient/Family Education

  • Instruct patient to take dose in the evening without regard to meals.
  • If patient is also taking a bile-acid sequestrant, recommend that cerivastatin be taken ³ 2 hr after the sequestrant.
  • Explain that full effectiveness of drug may not occur for up to 4 wk after initiation of therapy.
  • Teach dietary habits that reduce cholesterol and saturated fats.
  • Emphasize importance of follow-up visits to monitor drug effectiveness.
  • Instruct patient to report the following symptoms to the health care provider: any unexplained muscle pain, tenderness, or weakness, especially if accompanied by fever or malaise; yellowing of skin or eyes.
  • Caution female patients of childbearing potential that this medication must not be taken during pregnancy or when pregnancy is possible. Advise patient to use a reliable form of birth control while taking this drug.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.

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