Details About Generic Salt ::  Diflunis

Main Medicine Class:: Analgesic,Salicylate   

Dolobid,  Apo-Diflunisal, Novo-Diflunisal, Nu-Diflunisal
Class: Analgesic/Salicylate


Drugs Class ::

 Action Decreases inflammation and relieves pain by inhibiting prostaglandin synthesis and release.

Indications for Drugs ::

 Indications Relief of mild to moderate pain, rheumatoid arthritis and osteoarthritis.

Drug Dose ::


Mild to Moderate Pain

ADULTS: PO 500 to 1000 mg for first dose, then 250 to 500 mg q 8 to 12 hr.


ADULTS: PO 250 to 500 mg bid. Maximum dose: PO 750 mg bid.

Contraindication ::

 Contraindications Hypersensitivity to NSAIDs or aspirin.

Drug Precautions ::


Pregnancy: Category C. Lactation: Excreted in breast milk. Children: Not recommended for children < 12 yr. May increase risk of Reye’s syndrome; do not use if varicella infection or flu symptoms are suspected. Fluid retention: Use with caution in patients with CHF, hypertension or other conditions associated with fluid retention. History of peptic ulcer: Use carefully and closely monitor for GI bleeding or peptic ulcer; monitor patients with GI disease closely.


Drug Side Effects ::

 Adverse Reactions

CV: Peripheral edema. CNS: Headache; somnolence; insomnia; dizziness. DERM: Rash; erythema multiforme; photosensitivity. EENT: Angioedema; tinnitus. GI: Nausea; dyspepsia; GI pain; diarrhea; GI bleeding. GU: Renal impairment; interstitial nephritis; dysuria. HEMA: Thrombocytopenia; agranulocytosis; hemolytic anemia. HEPA Jaundice. RESP: Bronchospasm. OTHER: Anaphylaxis; hypersensitivity syndrome (eg, fever, chills, rash, liver or kidney dysfunction, leukopenia, thrombocytopenia, eosinophilia, DIC).

Drug Mode of Action ::  

 Action Decreases inflammation and relieves pain by inhibiting prostaglandin synthesis and release.

Drug Interactions ::


Antacids: Decreased plasma concentration of diflunisal. Cyclosporine: Increased nephrotoxic effect of cyclosporine possible. Methotrexate: Life-threatening methotrexate toxicity possible. Warfarin: Prothrombin time may increase; increased risk of bleeding.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Assess pain prior to and after administration of medication.
  • Monitor I&O. Notify physician if signs of renal dysfunction occur (decreased urine output, elevated BUN, elevated creatinine).
  • Include hepatic function in each assessment and notify physician if any signs or symptoms of hepatic dysfunction are noted (fatigue, jaundice, abdominal pain, elevated liver enzymes, dark urine).
  Drowsiness, vomiting, nausea, diarrhea, hyperventilation, tachycardia, sweating, tinnitus, disorientation, decreased urine output, cardiorespiratory arrest, stupor and coma; may lead to death.

Drug Storage/Management ::


  • Do not crush or allow patient to chew tablets.
  • Administer with milk or food to minimize gastric irritation, give patient generous amounts of water or other fluids to increase gastric emptying.

Drug Notes ::

 Patient/Family Education

  • Advise patient to swallow tablets whole and not to chew or crush them.
  • Explain that relief of arthritis may not occur for 1 wk to several wks.
  • Caution patients against taking products with aspirin or acetaminophen concurrently with diflunisal unless directed by physician.
  • Warn patient that this medication can precipitate Reye’s syndrome.
  • Advise patients to avoid exposure to sunlight and to use sunscreens or wear protective clothing to avoid photosensitivity reaction until tolerance is determined.
  • Inform patients that first dose tends to have slower onset of pain relief than other drugs with comparable effects.
  • Instruct patients to report immediately any signs of nephrotoxicity including decreased urine output, weight gain, edema, anorexia, nausea and vomiting.
  • Advise patients with history of GI problems to notify physician if abdominal pain, melena or hematemesis develops during therapy.
  • Advise patient to report degree of pain relief to physician.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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