Details About Generic Salt ::  Indapami

Main Medicine Class:: Thiazide diuretic   

(IN-DAP-uh-mide)

Lozol,  Apo-Indapamide, Novo-Indapamide, Nu-Indapamide

Class: Thiazide diuretic

Drugs Class ::

 Action Enhances excretion of sodium, chloride, and water by interfering with transport of sodium ions across renal tubular epithelium.

Indications for Drugs ::

 Indications Treatment of edema associated with CHF, hepatic cirrhosis, renal dysfunction, and corticosteroid or estrogen therapy; management of hypertension. Unlabeled use(s): Treatment of calcium nephrolithiasis, osteoporosis, or diabetes insipidus.

Drug Dose ::

 Route/Dosage

ADULTS: PO 1.25 to 5 mg q morning. Maximum 5 mg/day.

Contraindication ::

 Contraindications Hypersensitivity to thiazides, related diuretics, or sulfonamide-derived drugs; anuria.

Drug Precautions ::

 Precautions

Pregnancy: Category B. Lactation: May be excreted in breast milk. Hypersensitivity: May occur in patients with or without history of allergy or bronchial asthma; cross-sensitivity with sulfonamides may also occur. Electrolyte balance: Severe hyponatremia and hypokalemia may infrequently occur with recommended doses; more common in elderly females. Hepatic impairment: Minor alterations of fluid and electrolyte balance may precipitate hepatic coma; use with caution. Lipids: May cause increased concentrations of total triglycerides and LDL in some patients. Lupus erythematosus: Exacerbation or activation may occur. Postsympathectomy patients: Antihypertensive effects may be enhanced. Renal impairment: May precipitate azotemia; use with caution.

Drug Side Effects ::

 Adverse Reactions

CV: Orthostatic hypotension; palpitations. CNS: Dizziness; lightheadedness; vertigo; headache; weakness; restlessness; insomnia; drowsiness; fatigue; lethargy; anxiety; depression; nervousness. DERM: Rash; necrotizing angiitis; vasculitis; cutaneous vasculitis; pruritus. EENT: Blurred vision. GI: Anorexia; gastric irritation; epigastric distress; nausea; vomiting; abdominal pain/cramping/bloating; diarrhea; constipation; dry mouth. GU: Nocturia; impotence/reduced libido. HEMA: Neutropenia. META: Hyperglycemia; glycosuria; hyperuricemia. RESP: Rhinorrhea. OTHER: Muscle cramp or spasm; acute gout.

Drug Mode of Action ::  

 Action Enhances excretion of sodium, chloride, and water by interfering with transport of sodium ions across renal tubular epithelium.

Drug Interactions ::

 Interactions

Bile acid sequestrants: May reduce thiazide absorption; give thiazide ³ 2 hr before resin. Diazoxide: Hyperglycemia may occur. Digitalis glycosides: Diuretic-induced hypokalemia and hypomagnesemia may precipitate digitalis-induced arrhythmias. Lithium: May decrease renal excretion of lithium; monitor lithium levels. Loop diuretics: May result in synergistic effects and result in profound diuresis and serious electrolyte abnormalities. Sulfonylureas, insulin: May decrease hypoglycemic effect of sulfonylureas. May need to adjust dosage of sulfonylureas or insulin.

Drug Assesment ::

 Assessment/Interventions

• Obtain patient history, including drug history and any known allergies.
• Weigh patient daily.
• Assess feet, legs, and sacral area for edema daily.
• Measure I&O throughout therapy.
• Monitor BP, with patient lying and standing.
• Monitor renal function (nonprotein nitrogen, BUN, creatinine, glomerular filtration) and serum potassium, sodium, calcium, magnesium, blood pH, and uric acid as ordered.
• Assess for signs of metabolic alkalosis and hypokalemia.
• Report to physician signs of renal dysfunction (eg, anuria, oliguria); liver dysfunction (eg, dark urine, jaundice, pruritus); gout (eg, rising serum uric acid, joint pain); muscle weakness; cramps, nausea; dizziness; numbness; irregular heartbeat; irritability.

Drug Storage/Management ::

 Administration/Storage

• Administer as morning dose to prevent nocturia.
• Give with food or milk if nausea occurs.
• Store in tightly closed, light-resistant container at room temperature.

Drug Notes ::

 Patient/Family Education

• Tell patient to take medication early in day to prevent sleep problems.
• Instruct patient to take drug with food or milk to minimize GI irritation.
• Caution patient to avoid exposure to sunlight and to use sunscreen or wear protective clothing to avoid photosensitivity reaction.
• Instruct patients with diabetes to report increased blood glucose levels.
• Caution patients to avoid sudden position changes to prevent orthostatic hypotension.
• Advise patients to include in diet foods that are high in potassium (eg, bananas, broccoli, dried fruits, grapefruit, lima beans, nuts, oranges).
• Tell patient to report decrease in urinary output, jaundice, muscle cramps, weakness, nausea, blurred vision, or dizziness.
• For patients being treated for hypertension, explain benefits of weight reduction, exercise, reduction of alcohol and sodium intake, cessation of smoking.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.