Details About Generic Salt ::  Levodopa

Main Medicine Class:: Antiparkinson   

Class: Antiparkinson


Drugs Class ::

 Action Crosses the blood-brain barrier and is converted to dopamine in basal ganglia and periphery.

Indications for Drugs ::

 Indications Treatment of idiopathic, postencephalitic and symptomatic parkinsonism. Unlabeled use(s): Relief of herpes zoster (shingles) pain and restless leg syndrome.

Drug Dose ::


ADULTS: PO 0.5 to 1 g/day in 2 to 4 divided doses initially. Increase dosage gradually in increments £ 0.75 g/day q 3 to 7 days as tolerated (maximum 8 g/day).

Contraindication ::

 Contraindications Narrow-angle glaucoma; concomitant MAO inhibitor therapy (excluding MAO inhibitor-type B agents such as selegiline); history of or suspected melanoma.

Drug Precautions ::


Pregnancy: Pregnancy category undetermined. Lactation: Undetermined. Do not use in nursing mothers. Children: Safety and efficacy in children < 12 yr not established. Concomitant conditions: Use cautiously in patients with severe cardiovascular or pulmonary disease; renal, hepatic or endocrine disease; affective disorder; major psychosis; and cardiac arrhythmias. Dosage reduction: Decrease levodopa dose by 75% to 80% when used in combination with carbidopa. MI: Administer cautiously to patients with history of MI who have residual arrhythmias. Administer drug in facility with coronary or intensive care unit. Psychiatric patients: Use cautiously. Observe all patients for development of depression or suicidal ideation. Upper GI hemorrhage: May occur in patients with prior history of peptic ulcer.


Drug Side Effects ::

 Adverse Reactions

CV: Cardiac irregularity or palpitation; orthostatic hypotension; hypertension; phlebitis. CNS: Ataxia; headache; dizziness; numbness; weakness; faintness; confusion; insomnia; nightmares; mental changes (eg, psychosis, paranoia, depression, dementia, hallucinations, delusions); agitation; anxiety; fatigue; euphoria; psychopathology; adventitious movements (eg, choreiform or dystonic movements); increased hand tremor; muscle twitching; trismus; bradykinesia (“on-off” phenomenon). DERM: Flushing; skin rash; sweating. EENT: Blepharospasm; diplopia; blurred vision; dilated pupils; impaired taste perception; oculogyric crisis. GI: Anorexia; nausea; vomiting; abdominal pain; distress; dry mouth; dysphagia; excessive salivation; bruxism; GI bleeding; duodenal ulcer. GU: Urine retention; urinary incontinence; priapism. HEMA: Hemolytic anemia; anemia; agranulocytosis; leukopenia. HEPA: Elevated AST, ALT, LDH. RESP: Bizarre breathing patterns. OTHER: Malaise; hot flashes; weight gain or loss; dark sweat or urine; latent Horner’s syndrome; elevated BUN, bilirubin, alkaline phosphatase and protein-bound iodine; activation of malignant melanoma.

Drug Mode of Action ::  

 Action Crosses the blood-brain barrier and is converted to dopamine in basal ganglia and periphery.

Drug Interactions ::


Anticholinergics, benzodiazepines, hydantoins, methionine, papaverine, pyridoxine, tricyclic antidepressants: May reduce the effectiveness of levodopa. MAO inhibitors (except selegiline): Causes hypertensive reactions.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Assess for skin lesions or history of malignant melanoma.
  • Determine if patient is receiving MAO inhibitor. MAO inhibitor therapy must be discontinued at least 3 wk before levodopa regimen is instituted.
  • Perform complete baseline assessment of parkinsonian signs and symptoms before instituting therapy.
  • Monitor BP closely for hypotension if patient is taking antihypertensives concurrently.
  • Assist with ambulation during initial phase of therapy because of dizziness due to hypotension.
  • Monitor protein intake because absorption of levodopa is decreased in the presence of high-protein foods.
  • If uncontrollable movements, mental changes (eg, depression, paranoia), palpitations, difficult urination or severe or persistent nausea and vomiting occur, notify physician.
  • Offer support to patient and family because relief of parkinsonian symptoms may take several weeks to months after therapy is initiated.
  Shock, coma, blepharospasm, arrhythmias, seizures, CNS depression, muscle twitching

Drug Storage/Management ::


  • Give medication with food to reduce nausea.
  • Tablets can be crushed and capsules opened for mixing with small amount of fruit juice for patients being given tube feedings.
  • Store at room temperature in light-resistant container.

Drug Notes ::

 Patient/Family Education

  • Advise patient to take medication with food.
  • Teach patient to avoid sudden position changes to avoid orthostatic hypotension.
  • Inform patient that fluctuation in effectiveness of levodopa sometimes occurs with long-term therapy. Instruct patient to notify physician if fluctuation in effectiveness is experienced.
  • Advise patient to avoid use of otc vitamins, fortified cereals and vitamin B 6, which reverse effects of levodopa.
  • Warn patient not to increase dosage in an attempt to reduce parkinsonian symptoms more quickly. Noticeable lessening of symptoms may take more than 6 mo to occur.
  • Advise patient to report the following symptoms to physician: Uncontrolled movements, mood or mental changes, irregular heartbeats, difficulty in urination, severe or persistent nausea or vomiting, worsening of parkinsonian symptoms.
  • Advise patient that levodopa may cause urine and perspiration to become dark, which is a harmless side effect.
  • Inform patient that drug may cause drowsiness and to use caution while driving or performing tasks that require mental alertness.
  • Instruct patient to take sips of water frequently, suck on ice chips or sugarless hard candy or chew sugarless gum if dry mouth occurs.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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