Details About Generic Salt ::  Methimaz

Main Medicine Class:: Antithyroid   

Class: Antithyroid


Drugs Class ::

 Action Inhibits synthesis of thyroid hormones.

Indications for Drugs ::

 Indications Long-term therapy of hyperthyroidism; amelioration of hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy.

Drug Dose ::


ADULTS: Initial dose: PO 15–60 mg/day in 3 equal doses at approximately 8-hr intervals. Maintenance: PO 5–15 mg/day. CHILDREN: Initial dose: PO 0.4 mg/kg/day. MAINTENANCE: PO Approximately ½ initial dose. Alternately, children may be given 0.5–0.7 mg/kg/day in 3 divided doses as initial therapy and 1/32/3 of initial dose for maintenance.

Contraindication ::

 Contraindications Use in nursing women.

Drug Precautions ::


Pregnancy: Category D. Lactation: Avoid nursing. Agranulocytosis: Potentially most serious side effect. Discontinue drug in presence of agranulocytosis, aplastic anemia, hepatitis, fever or exfoliative dermatitis. Hemorrhage: May cause hypoprothrombinemia and bleeding. Monitor PT.


Drug Side Effects ::

 Adverse Reactions

CNS: Paresthesias; neuritis; headache; vertigo; drowsiness; neuropathies; NS stimulation; depression. DERM: Rash; urticaria; pruritus; erythema nodosum; skin pigmentation; xfoliative dermatitis; lupus-like syndrome including splenomegaly, hepatitis, periarteritis, hypoprothrombinemia and bleeding. EENT: Loss of taste; sialadenopathy. GI: Nausea; vomiting; epigastric distress. GU: Nephritis. HEPA: Jaundice; hepatitis. HEMA: Inhibition of myelopoiesis (eg, agranulocytosis, granulocytopenia, thrombocytopenia); aplastic anemia; hypoprothrombinemia; periarteritis. OTHER: Abnormal hair loss; arthralgia; myalgia; edema; lymphadenopathy; drug fever; interstitial pneumonitis; insulin autoimmune syndrome.

Drug Mode of Action ::  

 Action Inhibits synthesis of thyroid hormones.

Drug Interactions ::


Anticoagulants: May decrease or increase anticoagulant action. Beta blockers: May increase effects of beta blockers, resulting in toxicity. Digoxin: May cause increase in effects of digitalis glycosides, including toxicity. Theophyllines: May alter theophylline clearance in hyperthyroid or hypothyroid patients.

Drug Assesment ::


  • Obtain patient history, including drug history and any known allergies.
  • Assess for history of liver disease.
  • Assess symptoms of hyperthyroidism that patient is experiencing.
  • Obtain baseline vital signs and monitor during treatment.
  • Obtain baseline hepatic blood work including bilirubin and liver enzymes.
  • Obtain baseline CBC and monitor carefully during first 2 months of treatment.
  • Obtain baseline thyroid levels and monitor monthly initially and q 2–3 mo for long-term therapy.
  • Monitor drug’s effects on hyperthyroid symptoms.
  • Monitor PT, especially before surgery, to assess increased risk of bleeding.
  • Observe for potential adverse reactions including rash or fever, and notify physician if any occur.
  Nausea, vomiting, epigastric distress, headache, fever, arthralgia, pruritus, edema, pancytopenia, agranulocytosis, exfoliative dermatitis, hepatitis, neuropathies, CNS stimulation or depression.

Drug Storage/Management ::


  • Administer around clock in 3 equal doses (ie, q 8 hr).
  • Administer each dose with same amount of food to facilitate uniform absorption.
  • Store in light-resistant container at room temperature.

Drug Notes ::

 Patient/Family Education

  • Instruct patient in importance of taking proper dose exactly as scheduled.
  • Advise patient not to stop, start or adjust dose of any medications, including otc, without discussing with physician.
  • Explain to patient the importance of complying with follow-up appointments and lab work.
  • Instruct patient to check pulse daily.
  • Advise patient that iodine-restrictive diet may be necessary.
  • Inform patient that response to therapy may take months.
  • Instruct patient to report these symptoms to physician: rash, fever, sore throat, bruising or signs of infection or jaundice.
  • Advise patient that drug may cause drowsiness and to use caution while driving or performing other tasks requiring mental alertness.

Disclaimer ::

The Information available on this site is for only Informational Purpose , before any use of this information please consult your Doctor .Price of the drugs indicated above may not match to real price due to many possible reasons may , including local taxes etc.. These are only approximate indicative prices of the drug.


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